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MERTK Polyclonal antibody, PBS Only

MERTK Polyclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 27900-1-PBS

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Synonyms

验证数据展示

  • WB analysis using 27900-1-AP (same clone as 27900-1-PBS)

    WB analysis using 27900-1-AP (same clone as 27900-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 27900-1-AP (MERTK antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27900-1-PBS in a different storage buffer formulation.

  • IHC staining of rat liver using 27900-1-AP (same clone as 27900-1-PBS)

    IHC staining of rat liver using 27900-1-AP (same clone as 27900-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat liver tissue slide using 27900-1-AP (MERTK antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27900-1-PBS in a different storage buffer formulation.

  • IHC staining of human lung using 27900-1-AP (same clone as 27900-1-PBS)

    IHC staining of human lung using 27900-1-AP (same clone as 27900-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung tissue slide using 27900-1-AP (MERTK antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27900-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse lung using 27900-1-AP (same clone as 27900-1-PBS)

    IHC staining of mouse lung using 27900-1-AP (same clone as 27900-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse lung tissue slide using 27900-1-AP (MERTK antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27900-1-PBS in a different storage buffer formulation.

产品信息

27900-1-PBS targets MERTK in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity human, mouse, rat
Immunogen MERTK fusion protein Ag27540 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name c-mer proto-oncogene tyrosine kinase
Synonyms
Calculated Molecular Weight 999 aa, 110 kDa
Observed Molecular Weight160-180 kDa
GenBank Accession NumberBC114918
Gene Symbol MERTK
Gene ID (NCBI) 10461
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ12866
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

MerTK (Mer tyrosine kinase), also known as RP38, c-Eyk, c-mer, and Tyro12, was first cloned from a human B lymphoblastoid expression library (PMID:8086340) and is one of the TAM (Tyro-3, Axl, and MerTK) receptor tyrosine kinase (RTK) family (PMID:23833304). Although this RTK, like others, can promote tumor cell proliferation to some extent, MERTK primarily lends tumor cells crucial survival advantages while promoting invasion, migration and metastasis, drug resistance, and, in the innate immune system, suppressing anti-tumor immunity (PMID:32417270). The multiple MERTK species observed are likely due to posttranslational modifications (PMID: 23585477).