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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • WB analysis using 27900-1-AP (same clone as 27900-1-PBS)

    WB analysis using 27900-1-AP (same clone as 27900-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 27900-1-AP (MERTK antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27900-1-PBS in a different storage buffer formulation.

  • IHC staining of rat liver using 27900-1-AP (same clone as 27900-1-PBS)

    IHC staining of rat liver using 27900-1-AP (same clone as 27900-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat liver tissue slide using 27900-1-AP (MERTK antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27900-1-PBS in a different storage buffer formulation.

  • FC experiment of Jurkat using 27900-1-AP (same clone as 27900-1-PBS)

    FC experiment of Jurkat using 27900-1-AP (same clone as 27900-1-PBS)

    1x10^6 Jurkat cells were intracellularly stained with 0.25 ug MERTK Polyclonal antibody (27900-1-AP) and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2)(red), or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 27900-1-PBS in a different storage buffer formulation.

  • IHC staining of human lung using 27900-1-AP (same clone as 27900-1-PBS)

    IHC staining of human lung using 27900-1-AP (same clone as 27900-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung tissue slide using 27900-1-AP (MERTK antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27900-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse lung using 27900-1-AP (same clone as 27900-1-PBS)

    IHC staining of mouse lung using 27900-1-AP (same clone as 27900-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse lung tissue slide using 27900-1-AP (MERTK antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27900-1-PBS in a different storage buffer formulation.

MERTK Polyclonal antibody, PBS Only

MERTK Polyclonal Antibody for WB, IHC, FC (Intra), Indirect ELISA
Cat No. 27900-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, FC (Intra), Indirect ELISA

别名

Receptor tyrosine kinase MerTK, Proto-oncogene c-Mer, Proto oncogene c Mer, MER, EC:2.7.10.1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

27900-1-PBS targets MERTK in WB, IHC, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, FC (Intra), Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 MERTK fusion protein Ag27540 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 c-mer proto-oncogene tyrosine kinase
别名 Receptor tyrosine kinase MerTK, Proto-oncogene c-Mer, Proto oncogene c Mer, MER, EC:2.7.10.1
计算分子量 999 aa, 110 kDa
观测分子量160-180 kDa
GenBank蛋白编号BC114918
基因名称 MERTK
Gene ID (NCBI) 10461
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ12866
储存缓冲液 PBS Only
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

MerTK (Mer tyrosine kinase), also known as RP38, c-Eyk, c-mer, and Tyro12, was first cloned from a human B lymphoblastoid expression library (PMID:8086340) and is one of the TAM (Tyro-3, Axl, and MerTK) receptor tyrosine kinase (RTK) family (PMID:23833304). Although this RTK, like others, can promote tumor cell proliferation to some extent, MERTK primarily lends tumor cells crucial survival advantages while promoting invasion, migration and metastasis, drug resistance, and, in the innate immune system, suppressing anti-tumor immunity (PMID:32417270). The multiple MERTK species observed are likely due to posttranslational modifications (PMID: 23585477).