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MOSC2 Recombinant antibody, PBS Only (Capture)

MOSC2 Uni-rAbTM Recombinant Antibody for WB, IHC, Cytometric bead array, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, Cytometric bead array, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

240747G6

Cat no : 83705-2-PBS

Print datasheet

Synonyms

Molybdenum cofactor sulfurase C-terminal domain-containing protein 2, Moco sulfurase C-terminal domain-containing protein 2, Mitochondrial amidoxime reducing component 2, mARC2, EC:1.7.-.-

验证数据展示

  • WB analysis using 83705-2-RR (same clone as 83705-2-PBS)

    WB analysis using 83705-2-RR (same clone as 83705-2-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 83705-2-RR (MOSC2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83705-2-PBS in a different storage buffer formulation.

  • IHC staining of human stomach cancer using 83705-2-RR (same clone as 83705-2-PBS)

    IHC staining of human stomach cancer using 83705-2-RR (same clone as 83705-2-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 83705-2-RR (MOSC2 antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 83705-2-PBS in a different storage buffer formulation.

  • IHC staining of human stomach cancer using 83705-2-RR (same clone as 83705-2-PBS)

    IHC staining of human stomach cancer using 83705-2-RR (same clone as 83705-2-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 83705-2-RR (MOSC2 antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 83705-2-PBS in a different storage buffer formulation.

  • Cytometric bead array standard curve of MP00646-2

    Cytometric bead array standard curve of MP00646-2

    Cytometric bead array standard curve of MP00646-2, MOSC2 Recombinant Matched Antibody Pair, PBS Only. Capture antibody: 83705-2-PBS. Detection antibody: 83705-1-PBS. Standard: Ag20694. Range: 0.313-40 ng/mL.

  • Affinity and Kinetic Characterization of 83705-2-RR

    Affinity and Kinetic Characterization of 83705-2-RR

    Biolayer interferometry (BLl) kinetic assays of 83705-2-RR against Human MOSC2 were performed. The affinity constant is 0.473 nM.

产品信息

83705-2-PBS targets MOSC2 as part of a matched antibody pair:

MP00646-2: 83705-2-PBS capture and 83705-1-PBS detection (validated in Cytometric bead array)

Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

Tested Applications WB, IHC, Cytometric bead array, Indirect ELISA Application Description
Tested Reactivity human, mouse, rat
Immunogen MOSC2 fusion protein Ag20694 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name MOCO sulphurase C-terminal domain containing 2
Synonyms Molybdenum cofactor sulfurase C-terminal domain-containing protein 2, Moco sulfurase C-terminal domain-containing protein 2, Mitochondrial amidoxime reducing component 2, mARC2, EC:1.7.-.-
Calculated Molecular Weight 335 aa, 38 kDa
Observed Molecular Weight 35-38 kDa
GenBank Accession NumberBC011973
Gene Symbol MOSC2
Gene ID (NCBI) 54996
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ969Z3
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

MOSC domain-containing protein 2 (also known as MOSC2), also known as MARC2, is a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. Also, MOSC2 may be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. The reductase activity is regulated under adipogenic conditions, and down-regulation of the terminal component MOSC2 resulted in decreased lipid synthesis, suggesting a possible physiological role of this enzyme system and its component MOSC2 in lipogenesis(PMID: 22203676).