MTHFD2 Monoclonal antibody, PBS Only

MTHFD2 Monoclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

Human, Mouse

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1B4B6

Cat no : 68524-1-PBS

Print datasheet

Synonyms

MTHFD2



Planning an IHC experiment? We recommend our IHCeasy MTHFD2 Ready-To-Use IHC Kit. MTHFD2 primary antibody included.

产品信息

68524-1-PBS targets MTHFD2 in WB, IHC, Indirect ELISA applications and shows reactivity with Human, Mouse samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity Human, Mouse
Immunogen MTHFD2 fusion protein Ag33605 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Synonyms MTHFD2
Calculated Molecular Weight 350 aa, 38 kDa
Observed Molecular Weight 33-38 kDa
GenBank Accession NumberBC017054
Gene Symbol MTHFD2
Gene ID (NCBI) 10797
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP13995
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a folate-coupled mitochondrial metabolic enzyme characterized by methylenetetrahydrofolate dehydrogenase and cyclohydrolase activity. It was demonstrated that suppression of MTHFD2 inhibits methylation reactions, decreases protein synthesis and disrupts redox homeostasis, which may ultimately result in significant changes in cellular metabolic phenotype. MTHFD2 is reported to be up‐regulated in various tumours, such as lung adenocarcinoma(PMID: 34121323) and breast cancer(PMID: 34007312).