验证数据展示
产品信息
CL488-60331 targets NF200 in applications and shows reactivity with human, pig samples.
| 经测试应用 | Application Description |
| 经测试反应性 | human, pig |
| 免疫原 | NF200 fusion protein Ag13517 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG2a |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | neurofilament, heavy polypeptide |
| 别名 | 200 kDa neurofilament protein, KIAA0845, NEFH, neurofilament, NF, NF H, NFH |
| 计算分子量 | 112 kDa |
| 观测分子量 | 200 kDa |
| GenBank蛋白编号 | BC014185 |
| 基因名称 | NF-H |
| Gene ID (NCBI) | 4744 |
| 偶联类型 | CoraLite® Plus 488 Fluorescent Dye |
| 最大激发/发射波长 | 493 nm / 522 nm |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P12036 |
| 储存缓冲液 | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA , pH 7.3 |
| 储存条件 | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
NEFH, also named as KIAA0845 and NFH, Belongs to the intermediate filament family. It has an important function in mature axons that is not subserved by the two smaller NF proteins. Neurofilaments are the 10nm intermediate filaments found specifically in neurons. They are a major component of the cell's cytoskeleton, and provide support for normal axonal radial growth. Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. The names given to the three major neurofilament subunits are based upon the apparent molecular weight of the mammalian subunits on SDS-PAGE:NF-L, 65-68kd; NF-M,145-160kd and NF-H, 200-220kd. This antibody recognize NEFH only.