PE Anti-Mouse NK1.1 (CD161) (PK136)
NK1.1 (CD161) Monoclonal Antibody for FC
Host / Isotype
Mouse / IgG2a, kappa
Reactivity
Mouse and More (1)
Applications
FC
Conjugate
PE Fluorescent Dye
CloneNo.
PK136
验证数据展示
经过测试的应用
Positive FC detected in | mouse splenocytes |
推荐稀释比
Application | Dilution |
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This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
发表文章中的应用
FC | See 1 publications below |
产品信息
PE-65138 targets NK1.1 (CD161) in FC applications and shows reactivity with Mouse samples.
Tested Applications | FC Application Description |
Cited Applications | FC |
Tested Reactivity | Mouse |
Cited Reactivity | mouse |
Immunogen | NK-1+ cells from mouse spleen and bone marrow 种属同源性预测 |
Host / Isotype | Mouse / IgG2a, kappa |
Class | Monoclonal |
Type | Antibody |
Full Name | killer cell lectin-like receptor subfamily B member 1A |
Synonyms | CD161, Klrb1a, Ly55a, NK1.1, NK1.1 (CD161), NKR P1A, Nkrp1 a, NKRP12, Nkrp1a |
GenBank Accession Number | BC120707 |
Gene Symbol | NK1.1 |
Gene ID (NCBI) | 17057 |
RRID | AB_2883920 |
Conjugate | PE Fluorescent Dye |
Excitation/Emission Maxima Wavelengths | 496 nm, 565 nm / 578 nm |
Form | Liquid |
Purification Method | Affinity purification |
UNIPROT ID | P27811 |
Storage Buffer | Phosphate based buffer with 0.09% sodium azide and 0.1% gelatin, pH 7.2. |
Storage Conditions | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
背景介绍
NK1.1 (CD161), also known as KLRB1 or NKR-P1A, is a type II transmembrane C-type lectin-like receptor and is expressed on the cell membrane as disulfide-linked homodimer (PMID: 8077657). It is expressed by the majority of NK cells and subsets of peripheral T cells, including both CD4+ and CD8+ T cells, and is expressed preferentially on adult T cells with a "memory" antigenic phenotype (PMID: 8077657; 22566826). Expression of CD161 correlates with the cytotoxic function of CD16+ NK cells, and ligation of CD161 with its ligand LLT1 inhibits NK cell cytotoxicity and cytokine secretion (PMID: 29686665).
实验方案
Product Specific Protocols | |
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FC protocol for PE NK1.1 (CD161) antibody PE-65138 | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |
发表文章
Species | Application | Title |
---|---|---|
Nat Nanotechnol A bispecific nanosystem activates endogenous natural killer cells in the bone marrow for haematologic malignancies therapy |