CoraLite® Plus 488-conjugated Neuroserpin Monoclonal antibody
Neuroserpin Monoclonal Antibody for IF/ICC
Host / Isotype
Mouse / IgG1
Reactivity
human, rat, pig
Applications
IF/ICC
Conjugate
CoraLite® Plus 488 Fluorescent Dye
CloneNo.
1G4C6
验证数据展示
经过测试的应用
| Positive IF/ICC detected in | U-251 cells |
For other applications, we recommend the unconjugated version of this antibody, 66997-1-Ig
推荐稀释比
| Application | Dilution |
|---|---|
| Immunofluorescence (IF)/ICC | IF/ICC : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
CL488-66997 targets Neuroserpin in IF/ICC applications and shows reactivity with human, rat, pig samples.
| Tested Applications | IF/ICC Application Description |
| Tested Reactivity | human, rat, pig |
| Immunogen | Neuroserpin fusion protein Ag28636 种属同源性预测 |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | serpin peptidase inhibitor, clade I (neuroserpin), member 1 |
| Synonyms | Serpin I1, PI-12, PI12, PI 12, Peptidase inhibitor 12 |
| Calculated Molecular Weight | 410 aa, 47 kDa |
| Observed Molecular Weight | 46 kDa |
| GenBank Accession Number | BC018043 |
| Gene Symbol | Neuroserpin |
| Gene ID (NCBI) | 5274 |
| Conjugate | CoraLite® Plus 488 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 493 nm / 522 nm |
| Form | Liquid |
| Purification Method | Protein G purification |
| UNIPROT ID | Q99574 |
| Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at -20°C. Avoid exposure to light. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Neuroserpin is a member of the serpin family of serine protease inhibitors predominantly expressed in the nervous system, such as s the cerebral cortex, hippocampus and the spinal cord.Neuroserpin exerts protective effects in neurons against excitotoxicity both in vitro and in vivo. Its proteolytic inhibitory activity is shown to protect neurons against damage caused by plasmin activation. Mice overexpressing neuroserpin exhibited loss of tPA activity in the brain. Overexpression of neuroserpin in primary neurons leads to increased dendritic arborization and altered dendritic spine shape.
实验方案
| Product Specific Protocols | |
|---|---|
| IF protocol for CL Plus 488 Neuroserpin antibody CL488-66997 | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |