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CoraLite® Plus 488-conjugated Noggin Monoclonal antibody

Noggin Monoclonal Antibody for

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

Conjugate

CoraLite® Plus 488 Fluorescent Dye

CloneNo.

2A11C1

Cat No : CL488-69010

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Synonyms

NeutraKine® Noggin, NOG, noggin, SYM1, SYNS1

验证数据展示

For other applications, we recommend the unconjugated version of this antibody, 69010-1-Ig

产品信息

CL488-69010 targets Noggin in applications and shows reactivity with Human samples.

Tested Applications Application Description
Tested Reactivity Human
Immunogen Noggin fusion protein HZ-1118 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name noggin
Synonyms NeutraKine® Noggin, NOG, noggin, SYM1, SYNS1
Gene Symbol Noggin
Gene ID (NCBI) 9241
RRIDAB_2919566
Conjugate CoraLite® Plus 488 Fluorescent Dye
Excitation/Emission Maxima Wavelengths493 nm / 522 nm
Form Liquid
Purification MethodProtein G purification
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Noggin is an extracellular polypeptide acting as an antagonist of bone morphogenetic proteins (BMPs) regulating embryonal development. Noggin inhibits activity of BMP-2, -4, -7, -13, and -14. Noggin is present extracellularly in the matrix or retained at the cell surface via interaction with heparin sulfate proteoglycans. In early development stages, Noggin is produced by the Spemann organizer, allowing dorsal-ventral patterning of BMPs (PMID: 8752214). Subsequently, Noggin is expressed by the notochord regulating BMP-4 signaling in neurogenesis. Additionally, Noggin is present during development in the dermal papilla, connective tissue of the hair follicle, lens, retina, and periocular mesenchyme, as well as in the mesoderm lineage regulating development of the bone, cartilage, and muscles.

This antibody is used to Block/Neutralize Noggin protein.