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验证数据展示

  • WB analysis of MCF-7 using 67336-1-Ig (same clone as 67336-1-PBS)

    WB analysis of MCF-7 using 67336-1-Ig (same clone as 67336-1-PBS)

    WB result of ODC1 antibody (67336-1-Ig; 1:30000; incubated at room temperature for 1.5 hours) with sh-Control and sh-ODC1 transfected MCF-7 cells. This data was developed using the same antibody clone with 67336-1-PBS in a different storage buffer formulation.

  • WB analysis of MCF-7 using 67336-1-Ig (same clone as 67336-1-PBS)

    WB analysis of MCF-7 using 67336-1-Ig (same clone as 67336-1-PBS)

    MCF-7 cells were subjected to SDS PAGE followed by western blot with 67336-1-Ig (ODC1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67336-1-PBS in a different storage buffer formulation.

  • IF Staining of MCF-7 using 67336-1-Ig (same clone as 67336-1-PBS)

    IF Staining of MCF-7 using 67336-1-Ig (same clone as 67336-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed MCF-7 cells using ODC1 antibody (67336-1-Ig, Clone: 2A1E3 ) at dilution of 1:1000 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L) (SA00013-1). This data was developed using the same antibody clone with 67336-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

ODC1 Monoclonal antibody, PBS Only

ODC1 Monoclonal Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 67336-1-PBS
CloneNo. 2A1E3

Host / Isotype

Mouse / IgG1

Reactivity

human

Applications

WB, IF/ICC, Indirect ELISA

Synonyms

ODC, EC:4.1.1.17, 2A1E3

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size: 

-/ -

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产品信息

67336-1-PBS targets ODC1 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, IF/ICC, Indirect ELISA Application Description
Tested Reactivity human
Immunogen ODC1 fusion protein Ag10927 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name ornithine decarboxylase 1
Synonyms ODC, EC:4.1.1.17, 2A1E3
Calculated Molecular Weight 461 aa, 51 kDa
Observed Molecular Weight 51 kDa
GenBank Accession NumberBC025296
Gene Symbol ODC1
Gene ID (NCBI) 4953
RRIDAB_2882594
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP11926
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Ornithine decarboxylase (ODC) is also named as ODC1 and belongs to the Orn/Lys/Arg decarboxylase class-II family. It catalyzes the conversion of ornithine to putrescine, the first step and a major site of regulation of polyamine biosynthesis. The level of ODC is known to be controlled at several sites, namely transcription, translation, and enzyme degradation. Polyamines can stimulate the degradation of ODC as a type of negative feedback control (PMID:8486633). This protein can be phosphorylated in vivo (PMID:8798774). ODC1 can form a homodimer and only the dimer is catalytically active, as the active sites are constructed of residues from both monomers (PMID: 10623504). The molecular mass of ODC1 is 51 kDa, and the homodimer is 106 kDa.