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Host
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Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
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Compatible Species
0
Conjugate
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验证数据展示

  • WB analysis using 84657-4-RR (same clone as 84657-4-PBS)

    WB analysis using 84657-4-RR (same clone as 84657-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84657-4-RR (PSPC1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84657-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84657-4-RR

    Affinity and Kinetic Characterization of 84657-4-RR

    Biolayer interferometry (BLl) kinetic assays of 84657-4-RR against Human PSPC1 were performed. The affinity constant is 0.68 nM.

PSPC1 Recombinant antibody, PBS Only

PSPC1 Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA
Cat No. 84657-4-PBS

产品说明书

CloneNo. 242158G7

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, Indirect ELISA

别名

PSPC 1, PSP1, 242158G7

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy PSPC1 Ready-To-Use IHC Kit. PSPC1 primary antibody included.

产品信息

84657-4-PBS targets PSPC1 in WB, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human
免疫原 PSPC1 fusion protein Ag10136 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 paraspeckle component 1
别名 PSPC 1, PSP1, 242158G7
计算分子量 523 aa, 59 kDa
观测分子量 66 kDa
GenBank蛋白编号BC014184
基因名称 PSPC1
Gene ID (NCBI) 55269
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDQ8WXF1
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PSPC1 (paraspeckle component 1), a known paraspeckle biomarker, is a putative transcription factor that belongs to the Drosophila behavior/human splicing (DBHS) family. PSPC1 was recently identified as a contextual determinant of tumor progression in multiple cancer types involving oncogenic reprogramming to switch proapoptotic TGF-β to prometastatic TGF-β via hijacking of Smad2/3 targeting. Upregulated PSPC1 is correlated with advanced tumor stages and poor survival of patients with breast, lung, and liver cancers. Upregulated PSPC1 potentiates expression of mesenchymal markers, EMT transcription factors (EMT-TF), cancer stem-like cell transcription factors (CSC-TF), and c-Myc-related proliferation genes, thus promoting migration, invasion, spheroid formation, tumor formation, and metastasis.