验证数据展示
产品信息
83981-4-PBS targets Securin as part of a matched antibody pair:
MP00876-1: 83981-2-PBS capture and 83981-4-PBS detection (validated in Cytometric bead array)
MP00876-2: 83981-1-PBS capture and 83981-4-PBS detection (validated in Cytometric bead array)
MP00876-3: 83981-4-PBS capture and 83981-3-PBS detection (validated in Cytometric bead array)
Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.
This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.
Tested Applications | IF/ICC, FC (Intra), Cytometric bead array, Indirect ELISA Application Description |
Tested Reactivity | human |
Immunogen | Securin fusion protein Ag12670 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Full Name | pituitary tumor-transforming 1 |
Synonyms | PTTG1, PTTG, Pituitary tumor-transforming gene 1 protein, hPTTG, Esp1-associated protein |
Calculated Molecular Weight | 202 aa, 22 kDa |
GenBank Accession Number | BC101834 |
Gene Symbol | Securin |
Gene ID (NCBI) | 9232 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | O95997 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Securin, also known as the pituitary tumor transforming gene (PTTG1), was first isolated from rat pituitary tumor cells. Securin is a multi-functional protein that regulates sister chromatin segregation in mitosis, DNA repair, gene transcription, metabolism, and organ development. Securin is normally expressed in tissues with high proliferative activity, including the spleen, thymus gland, and testis, whereas it is rarely expressed in differentiated mature tissues (PMID: 22563433, PMID: 36123907). The calculated molecular weight of Securin is 22 kDa. With post-translational modification, the molecular weight of Securin will be migrated to 28 kDa.