Phospho-Cardiac Troponin I (Ser23/24) Recombinant antibody, PBS Only

Phospho-Cardiac Troponin I (Ser23/24) Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA
Cat No. 85002-1-PBS
CloneNo. 241982B1

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

cTnI, Cardiac troponin I, TNNI3, 241982B1

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size: 

-/ -


Planning an IHC experiment? We recommend our IHCeasy TNNI3 Ready-To-Use IHC Kit. TNNI3 primary antibody included.

产品信息

85002-1-PBS targets Phospho-Cardiac Troponin I (Ser23/24) in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human, mouse
Immunogen Peptide 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name troponin I type 3 (cardiac)
Synonyms cTnI, Cardiac troponin I, TNNI3, 241982B1
Calculated Molecular Weight 210 aa, 24 kDa
Observed Molecular Weight26 kDa
GenBank Accession NumberBC096165
Gene Symbol Cardiac Troponin I
Gene ID (NCBI) 7137
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP19429
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Cardiac Troponin I (cTnI) is produced by cardiac muscle. To date, most investigative effort in phosphorylation mediated regulation of cTnI function has focused on the actions of PKA and PKC. Evidence from studies in a variety of systems, ranging from reconstituted myofilament proteins to cultured myocytes or transgenic animals with heterologous expression of modified cTnI proteins, indicates that PKA-mediated functional effects (eg, decreased myofilament Ca2 sensitivity) are mediated principally through the phosphorylation of Ser22/23 (equivalent to Ser23/24, including the initiating Met, in the rodent sequence) within the unique N-terminal extension of cTnI. (PMID: 15514163)

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