Phospho-STAT1 (Tyr701) Recombinant antibody, PBS Only
Phospho-STAT1 (Tyr701) Recombinant Antibody for WB,Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
Human
Applications
WB,Indirect ELISA
Conjugate
Unconjugated
CloneNo.
1C5
验证数据展示
Planning an IHC experiment? We recommend our IHCeasy STAT1 Ready-To-Use IHC Kit. STAT1 primary antibody included.
产品信息
82674-10-PBS targets Phospho-STAT1 (Tyr701) in WB, Indirect ELISA applications and shows reactivity with Human samples.
Tested Applications | WB,Indirect ELISA Application Description |
Tested Reactivity | Human |
Immunogen | Peptide 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Full Name | signal transducer and activator of transcription 1, 91kDa |
Synonyms | DKFZp686B04100, ISGF 3, Phospho-STAT1 (Tyr701), STAT1, STAT91 |
Calculated Molecular Weight | 83 kDa |
Observed Molecular Weight | 84-91 kDa |
GenBank Accession Number | BC002704 |
Gene Symbol | STAT1 |
Gene ID (NCBI) | 6772 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | P42224 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
背景介绍
STAT1 (signal transducers and activators of transcription 1) is a member of the STAT protein family. STAT family members are phosphorylated by the receptor associated kinases, and then form homo-or heterodimers that translocate to the cell nucleus where they act as transcription activators. The phosphorylation of STAT1 at Tyr701 promotes the dimerization of STAT1 and its translocation into the nucleus where it binds the GAS promoter to allow the transcription of inflammatory response genes(PMID: 31408005). The transcript of STAT1 undergoes alternative splicing, resulting in two isoforms: STAT1α (91 kDa) and STAT1β (84 kDa)(PMID: 20159032).