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Phospho-TAU (Thr231) Recombinant antibody, PBS Only

Phospho-TAU (Thr231) Uni-rAbTM Recombinant Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Conjugate

Unconjugated

CloneNo.

240632B1

Cat no : 80101-7-PBS

Print datasheet

Synonyms

MAPT, TAU, Microtubule-associated protein tau, MAPTL, DDPAC

验证数据展示

  • WB analysis using 80101-7-RR (same clone as 80101-7-PBS)

    WB analysis using 80101-7-RR (same clone as 80101-7-PBS)

    Non-treated SH-SY5Y cells, phosphatase inhibitor treated SH-SY5Y cells and λ phosphatase treated SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 80101-7-RR (Phospho-TAU (Thr231) antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. The membrane was stripped and re-blotted with Alpha Tubulin (66031-1-Ig) antibody as a loading control. This data was developed using the same antibody clone with 80101-7-PBS in a different storage buffer formulation.

产品信息

80101-7-PBS targets Phospho-TAU (Thr231) in WB, ELISA applications and shows reactivity with human samples.

Tested Applications WB, ELISA Application Description
Tested Reactivity human
Immunogen Peptide 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name microtubule-associated protein tau
Synonyms MAPT, TAU, Microtubule-associated protein tau, MAPTL, DDPAC
Calculated Molecular Weight 37-46, 79-81 kDa
Observed Molecular Weight50-80 kDa
GenBank Accession NumberBC000558
Gene Symbol TAU
Gene ID (NCBI) 4137
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP10636
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Tau (tubulin-associated unit) is a microtubule-associated protein (also known as MAPT), expressed mainly in neurons of the central nervous system. Its primary function is to modulate microtubule dynamics for maintaining axonal cytoskeleton. The Tau protein has six isoforms produced from a single gene through alternative RNA splicing. Isoforms differ in number of inserts at the N-terminal half and the number of repeats at the C-terminal half (3 repeat-3R; 4 repeat-4R). Tau is hyperphosphorylated during aging and in age-related neurodegenerative diseases such as Alzheimer's disease (AD) and fronto-temporal dementia. Hyperphosphorylation of Tau leads to the formation of neurofibrillary tangles (NFT) in the neurons and glia cells, which is one of the hallmarks of AD.