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Profilin 1 Monoclonal antibody, PBS Only

Profilin 1 Monoclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 67390-1-PBS

产品说明书

CloneNo. 3A12E8

宿主/亚型

Mouse / IgG2b

种属反应性

Human, Mouse, Rat

应用

WB, IHC, IF/ICC, Indirect ELISA

PFN1, profilin 1, Profilin I

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -


Planning an IHC experiment? We recommend our IHCeasy PFN1 Ready-To-Use IHC Kit. PFN1 primary antibody included.

产品信息

67390-1-PBS targets Profilin 1 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 Human, Mouse, Rat
免疫原 Profilin 1 fusion protein Ag29206 种属同源性预测
宿主/亚型 Mouse / IgG2b
抗体类别 Monoclonal
产品类型 Antibody
全称 profilin 1
别名 PFN1, profilin 1, Profilin I
计算分子量 140 aa, 15 kDa
观测分子量 13 kDa
GenBank蛋白编号BC006768
基因名称 Profilin 1
Gene ID (NCBI) 5216
RRIDAB_2882634
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP07737
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Profilin-1 (PFN1) plays an important role in the control of actin dynamics, and could represent an important therapeutic target in several diseases. PFN1 is identified as a huntingtin aggregation inhibitor, and may serves as a tumor-suppressor. PFN1 is crucial for the conversion of monomeric (G)-actin to filamentous (F)-actin. Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disorder resulting from motor neuron death. Cells expressing PFN1 mutants contain ubiquitinated, insoluble aggregates that in many cases contain the ALS-associated protein TDP-43. Recently, PFN1 is a potential biomarker for bladder cancer aggressiveness and may be of great clinical importance.

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