验证数据展示
产品信息
84516-6-PBS targets SAE1 in IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with human samples.
| Tested Applications | IF/ICC, FC (Intra), Indirect ELISA Application Description |
| Tested Reactivity | human |
| Immunogen | SAE1 fusion protein Ag0275 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Full Name | SUMO1 activating enzyme subunit 1 |
| Synonyms | SUMO-activating enzyme subunit 1, SUA1, Sentrin/SUMO activating protein AOS1, HSPC140, AOS1 |
| Calculated Molecular Weight | 38 kDa |
| GenBank Accession Number | BC000344 |
| Gene Symbol | SAE1 |
| Gene ID (NCBI) | 10055 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purfication |
| UNIPROT ID | Q9UBE0 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
SAE1(SUMO-activating enzyme subunit 1) is also named as AOS1, SUA1, UBLE1A and belongs to the ubiquitin-activating E1 family. SAE1 has a calculated molecular mass of 38 kD. SAE1 and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins(PMID:9920803). Western blot analysis of synchronized HeLa cells detectes increased AOS1 expression as cells progressed through S phase, followed by a substantial decrease in G2 phase. Immunofluorescence analysis shows AOS1 and UBA2 distributed throughout nuclei, but they are excluded from nucleoli.(PMID:11481243).