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验证数据展示

  • WB analysis using 68651-1-Ig

    WB analysis using 68651-1-Ig

    Various lysates were subjected to SDS PAGE followed by western blot with 68651-1-Ig (SORL1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

  • IF Staining of mouse cerebellum using 68651-1-Ig

    IF Staining of mouse cerebellum using 68651-1-Ig

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse cerebellum tissue using SORL1 antibody (68651-1-Ig, Clone: 2E7D9 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L) (SA00013-1). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

SORLA Monoclonal antibody

SORLA Monoclonal Antibody for WB, IF-P, ELISA
Cat No. 68651-1-Ig

产品说明书

CloneNo. 2E7D9

宿主/亚型

Mouse / IgG1

种属反应性

human

应用

WB, IF-P, ELISA

别名

SORL1, SORL 1, Low-density lipoprotein receptor relative with 11 ligand-binding repeats, LDLR relative with 11 ligand-binding repeats, C11orf32

缓冲液配方:  PBS and Azide
PBS and Azide
PBS Only
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -

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经过测试的应用

Positive WB detected inLNCaP cells
Positive IF-P detected inmouse cerebellum tissue
Planning an IHC experiment? We recommend our IHCeasy SORL1 Ready-To-Use IHC Kit. SORL1 primary antibody included.

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:1000-1:4000
Immunofluorescence (IF)-PIF-P : 1:200-1:800
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

68651-1-Ig targets SORLA in WB, IF-P, ELISA applications and shows reactivity with human samples.

经测试应用 WB, IF-P, ELISA Application Description
经测试反应性 human
免疫原 SORLA fusion protein Ag18445 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 sortilin-related receptor, L(DLR class) A repeats-containing
别名 SORL1, SORL 1, Low-density lipoprotein receptor relative with 11 ligand-binding repeats, LDLR relative with 11 ligand-binding repeats, C11orf32
计算分子量 2214 aa, 248 kDa
观测分子量 300 kDa
GenBank蛋白编号BC137171
基因名称 SORLA
Gene ID (NCBI) 6653
RRIDAB_3670393
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein G purification
UNIPROT IDQ92673
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

SorLA also known as SorL1 or LR11, is a multiligand receptor belonging to the LDL receptor superfamily. It is also a member of vacuolar protein sorting-10 (Vps10) family and is enriched in the brain. SorLA acts as an sorting receptor for APP and prevents amyloidogenic processing of APP. Downregulation of SorLA has been found in patients with sporadic Alzheimer disease (AD). Currently SorLA has emerged as a potential target for AD therapy. (25404298)

实验方案

Product Specific Protocols
WB protocol for SORLA antibody 68651-1-IgDownload protocol
IF protocol for SORLA antibody 68651-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols