验证数据展示
产品信息
68628-1-PBS targets STAM in WB, Indirect ELISA applications and shows reactivity with Human, mouse, rat samples.
经测试应用 | WB, Indirect ELISA Application Description |
经测试反应性 | Human, mouse, rat |
免疫原 | STAM fusion protein Ag33192 种属同源性预测 |
宿主/亚型 | Mouse / IgG2b |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 |
别名 | DKFZp686J2352, STAM, STAM 1, STAM1 |
计算分子量 | 59 kDa |
观测分子量 | 70 kDa |
GenBank蛋白编号 | BC030586 |
基因名称 | STAM |
Gene ID (NCBI) | 8027 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | Q92783 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
STAM, also named as STAM1, belongs to the STAM family. It is involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. STAM may also play a role in T-cell development. It is involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs). Together with HRS, STAM forms ESCRT-0. STAM was originally identified as an adaptor protein involved in cytokine signaling.(PMID:20505072)