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验证数据展示

  • WB analysis of K-562 using 67592-1-Ig

    WB analysis of K-562 using 67592-1-Ig

    K-562 cells were subjected to SDS PAGE followed by western blot with 67592-1-Ig (TERF1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

TERF1 Monoclonal antibody

TERF1 Monoclonal Antibody for WB, ELISA
Cat No. 67592-1-Ig
CloneNo. 1D10G4
Publications(1)

Host / Isotype

Mouse / IgG1

Reactivity

human

Applications

WB, ELISA and More (2)

Synonyms

Telomeric repeat-binding factor 1, t TRF1, PIN2, NIMA-interacting protein 2, hTRF1 AS

Formulation:  PBS and Azide
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Unconjugated
Size: 

-/ -

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经过测试的应用

Positive WB detected inK-562 cells, HEK-293 cells, Jurkat cells

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:6000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

67592-1-Ig targets TERF1 in WB, IP, ChIP, ELISA applications and shows reactivity with human samples.

Tested Applications WB, ELISA Application Description
Cited ApplicationsWB, IP, ChIP
Tested Reactivity human
Cited Reactivityhuman
Immunogen TERF1 fusion protein Ag12540 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name telomeric repeat binding factor (NIMA-interacting) 1
Synonyms Telomeric repeat-binding factor 1, t TRF1, PIN2, NIMA-interacting protein 2, hTRF1 AS
Calculated Molecular Weight 439 aa, 50 kDa
Observed Molecular Weight 48-50 kDa
GenBank Accession NumberBC029378
Gene Symbol TERF1
Gene ID (NCBI) 7013
RRIDAB_2918494
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP54274
Storage Buffer PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Telomeres are nucleoprotein complexes located at chromosome ends that consist of tandem arrays of TTAGGG repeats bound to specific proteins. Telomeres protect chromosome ends from degradation and end-to-end fusions, prevent activation of DNA damage checkpoints, and modulate the maintenance of telomeric DNA by telomerase. TERF1 (telomeric repeat-binding factor 1) binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. It's one component of the shelterin complex, which involved in the regulation of telomere length and protection.

实验方案

Product Specific Protocols
WB protocol for TERF1 antibody 67592-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
humanWB,IP,ChIP

Nat Commun

Transcription stress at telomeres leads to cytosolic DNA release and paracrine senescence

Authors - Athanasios Siametis
View Article