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验证数据展示

  • IF Staining of HepG2 using 82937-1-RR (same clone as 82937-1-PBS)

    IF Staining of HepG2 using 82937-1-RR (same clone as 82937-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using KAT5 antibody (82937-1-RR, Clone: 230181D5 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 82937-1-PBS in a different storage buffer formulation.

  • FC experiment of HCT 116 using 82937-1-RR (same clone as 82937-1-PBS)

    FC experiment of HCT 116 using 82937-1-RR (same clone as 82937-1-PBS)

    1x10^6 HCT 116 cells were intracellularly stained with 0.25 ug Anti-Human KAT5 (82937-1-RR, Clone:230181D5) and APC-Conjugated Goat Anti-Rabbit IgG(H+L)(red), or 0.25 ug Rabbit IgG control Rabbit PolyAb (30000-0-AP) (blue). Cells were fixed and permeabilized with True-Nuclear Transcription Factor Buffer Set. This data was developed using the same antibody clone with 82937-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 82937-1-RR

    Affinity and Kinetic Characterization of 82937-1-RR

    Biolayer interferometry (BLl) kinetic assays of 82937-1-RR against Human TIP60/KAT5 were performed. The affinity constant is below 1 pM.

TIP60/KAT5 Recombinant antibody, PBS Only

TIP60/KAT5 Uni-rAbTM Recombinant Antibody for IF/ICC, FC (Intra), Indirect ELISA
Cat No. 82937-1-PBS

产品说明书

CloneNo. 230181D5

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IF/ICC, FC (Intra), Indirect ELISA

别名

KAT5, EC:2.3.1.48, EC:2.3.1.-, cPLA2, cPLA(2)-interacting protein

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy KAT5 Ready-To-Use IHC Kit. KAT5 primary antibody included.

产品信息

82937-1-PBS targets TIP60/KAT5 in IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with human samples.

经测试应用 IF/ICC, FC (Intra), Indirect ELISA Application Description
经测试反应性 human
免疫原 TIP60/KAT5 fusion protein Ag1261 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 K(lysine) acetyltransferase 5
别名 KAT5, EC:2.3.1.48, EC:2.3.1.-, cPLA2, cPLA(2)-interacting protein
计算分子量 60 kDa
GenBank蛋白编号BC000166
基因名称 KAT5
Gene ID (NCBI) 10524
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ92993
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

KAT5, also named as The histone acetyltransferase (HAT) Tat interactive protein 60 kD belongs to the MYST protein family that contains atypical zinc finger and histone acetyltransferase domains. Also, KAT5 contains a chromodomain. KAT5 is a catalytic subunit of the NuA4 histone acetyltransferase complex. The NuA4 HAT complex plays a role in transcriptional activation of select genes mainly by acetylation of nucleosomal histone H4 and H2A, which influence nucleosome-DNA interaction and promotes interaction of the modified histones with other proteins that could regulate transcription positively. This complex also involves in the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, DNA repair and apoptosis.