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验证数据展示

  • FC experiment of Transfected HEK-293T using 98263-1-RR (same clone as 98263-1-PBS)

    FC experiment of Transfected HEK-293T using 98263-1-RR (same clone as 98263-1-PBS)

    1x10^6 HEK-293T cells or TMIGD2/CD28H transfected HEK-293T cells were stained with 0.25 ug Anti-Human TMIGD2/CD28H Rabbit Recombinant Antibody (98263-1-RR, Clone:241807A5) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98263-1-PBS in a different storage buffer formulation.

  • FC experiment of Transfected HEK-293T using 98263-1-RR (same clone as 98263-1-PBS)

    FC experiment of Transfected HEK-293T using 98263-1-RR (same clone as 98263-1-PBS)

    1x10^6 HEK-293T cells or TMIGD2/CD28H transfected HEK-293T cells were stained with 0.25 ug Anti-Human TMIGD2/CD28H Rabbit Recombinant Antibody (98263-1-RR, Clone: 241807A5) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98263-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98263-1-RR

    Affinity and Kinetic Characterization of 98263-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98263-1-RR against Human TMIGD2/CD28H were performed. The affinity constant is 171 nM.

Anti-Human TMIGD2/CD28H Rabbit Recombinant Antibody, PBS Only

TMIGD2/CD28H Uni-rAbTM Recombinant Antibody for FC
Cat No. 98263-1-PBS

产品说明书

CloneNo. 241807A5

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

TMIGD2/CD28, Immunoglobulin and proline-rich receptor 1, IGPR-1, IGPR1, CD28H

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

98263-1-PBS targets TMIGD2/CD28H in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 transmembrane and immunoglobulin domain containing 2
别名 TMIGD2/CD28, Immunoglobulin and proline-rich receptor 1, IGPR-1, IGPR1, CD28H
计算分子量 282 aa, 31 kDa
GenBank蛋白编号BC015655
基因名称 TMIGD2
Gene ID (NCBI) 126259
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDQ96BF3
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Transmembrane and immunoglobulin domain-containing protein 2 (TMIGD2, also known as CD28H and IGPR1), plays a role in cell-cell interaction, migration, and angiogenesis. Through interaction with HHLA2, it costimulates T-cells in the context of TCR-mediated activation and enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade (PMID: 22419821; 23784006). TMIGD2 has been associated with several diseases, particularly in the context of cancer. It is aberrantly expressed by human AML cells and can be used to identify and enrich functional LSCs (PMID: 38167704).