APC Anti-Human TNFR1/CD120a Rabbit Recombinant Antibody

TNFR1/CD120a Uni-rAbTM Recombinant Antibody for FC
Cat No. APC-98085

产品说明书

CloneNo. 241337H6

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

CD120a, TNFR1, TNFRSF1A, 241337H6, FPF

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  APC
规格: 

-/ -


经过测试的应用

Positive FC detected inhuman peripheral blood leukocytes

推荐稀释比

应用推荐稀释比
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.
Sample-dependent, Check data in validation data gallery.

产品信息

APC-98085 targets TNFR1/CD120a in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 Recombinant Protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 tumor necrosis factor receptor superfamily, member 1A
别名 CD120a, TNFR1, TNFRSF1A, 241337H6, FPF
计算分子量 455 aa, 50 kDa
GenBank蛋白编号BC010140
基因名称 TNFR1
Gene ID (NCBI) 7132
偶联类型 APC Fluorescent Dye
最大激发/发射波长650 nm / 660 nm
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP19438
储存缓冲液 PBS with 0.09% sodium azide and 0.5% BSA , pH 7.3
储存条件Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

背景介绍

Tumor necrosis factor (TNF) is a multifunctional cytokine that plays a key role in regulating inflammation, immune functions, host defense, and apoptosis (PMID: 16407280). TNF exists in soluble and membrane-bound forms. TNF signals through two distinct cell surface receptors, TNFR1 (TNFRSF1A, CD120a) and TNFR2 (TNFRSF1B, CD120b). Whereas TNFR1 is widely expressed, expression of TNFR2 is limited to cells of the immune system, endothelial cells, and nerve cells (PMID: 22053109). TNFR1, which contains a death domain (DD) within its intracytoplasmic region, is thought to be the key receptor for TNF signaling (PMID: 16407280). This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor.

实验方案

Product Specific Protocols
FC protocol for APC TNFR1/CD120a antibody APC-98085Download protocol
Standard Protocols
Click here to view our Standard Protocols
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