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TXNDC5 Recombinant antibody, PBS Only

TXNDC5 Uni-rAbTM Recombinant Antibody for WB, IHC, IF/ICC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, IF/ICC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

242195G7

Cat no : 84756-5-PBS

Print datasheet

Synonyms

Hcc 2, ERp46, ER protein 46, EndoPDI, EC:1.8.4.-

验证数据展示

  • WB analysis using 84756-5-RR (same clone as 84756-5-PBS)

    WB analysis using 84756-5-RR (same clone as 84756-5-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84756-5-RR (TXNDC5 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84756-5-PBS in a different storage buffer formulation.

  • IF Staining of HeLa using 84756-5-RR (same clone as 84756-5-PBS)

    IF Staining of HeLa using 84756-5-RR (same clone as 84756-5-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HeLa cells using TXNDC5 antibody (84756-5-RR, Clone: 242195G7 ) at dilution of 1:500 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 84756-5-PBS in a different storage buffer formulation.

  • IHC staining of human stomach cancer using 84756-5-RR (same clone as 84756-5-PBS)

    IHC staining of human stomach cancer using 84756-5-RR (same clone as 84756-5-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 84756-5-RR (TXNDC5 antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84756-5-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with TXNDC5 antibody included
  • IHC staining of human stomach cancer using 84756-5-RR (same clone as 84756-5-PBS)

    IHC staining of human stomach cancer using 84756-5-RR (same clone as 84756-5-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 84756-5-RR (TXNDC5 antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84756-5-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with TXNDC5 antibody included
  • Affinity and Kinetic Characterization of 84756-5-RR

    Affinity and Kinetic Characterization of 84756-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84756-5-RR against Human TXNDC5 were performed. The affinity constant is 2.31 nM.

Planning an IHC experiment? We recommend our IHCeasy TXNDC5 Ready-To-Use IHC Kit. TXNDC5 primary antibody included.

产品信息

84756-5-PBS targets TXNDC5 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, IHC, IF/ICC, Indirect ELISA Application Description
Tested Reactivity human
Immunogen TXNDC5 fusion protein Ag13965 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name thioredoxin domain containing 5 (endoplasmic reticulum)
Synonyms Hcc 2, ERp46, ER protein 46, EndoPDI, EC:1.8.4.-
Calculated Molecular Weight 432 aa, 48 kDa
Observed Molecular Weight 48 kDa
GenBank Accession NumberBC001199
Gene Symbol TXNDC5
Gene ID (NCBI) 81567
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDQ8NBS9
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TXNDC5, or Thioredoxin Domain Containing 5, is a protein-coding gene that plays a significant role in cellular processes, particularly in the endoplasmic reticulum (ER). This gene is essential for the proper functioning of the cellular environment, primarily through its involvement in the formation and rearrangement of disulfide bonds within proteins. Disulfide bonds are crucial for the stability and functionality of many proteins, and TXNDC5 facilitates these processes through its thioredoxin domains, which contain enzymatic activities that promote correct protein folding and maturation in the ER. Recent studies highlight the expression characteristics of TXNDC5 across various diseases. It has been implicated in the promotion of malignant diseases, suggesting a potential role in cancer biology and other pathological conditions. (PMID:25526565; 38629066)