CoraLite®594-conjugated Thyroglobulin Monoclonal antibody

Thyroglobulin Monoclonal Antibody for IF-P

Host / Isotype

Mouse / IgG2a

Reactivity

human

Applications

IF-P

Conjugate

CoraLite®594 Fluorescent Dye

CloneNo.

4D3C5

Cat no : CL594-60272

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Synonyms

AITD3, TG, TGN, thyroglobulin



经过测试的应用

Positive IF-P detected inhuman thyroid cancer tissue
For other applications, we recommend the unconjugated version of this antibody, 60272-1-Ig

推荐稀释比

ApplicationDilution
Immunofluorescence (IF)-PIF-P : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL594-60272 targets Thyroglobulin in IF-P applications and shows reactivity with human samples.

Tested Applications IF-P Application Description
Tested Reactivity human
Immunogen Thyroglobulin fusion protein Ag18070 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name thyroglobulin
Synonyms AITD3, TG, TGN, thyroglobulin
Calculated Molecular Weight 2768 aa, 305 kDa
GenBank Accession NumberBC140933
Gene Symbol Thyroglobulin
Gene ID (NCBI) 7038
RRIDAB_2919909
Conjugate CoraLite®594 Fluorescent Dye
Excitation/Emission Maxima Wavelengths588 nm / 604 nm
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP01266
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.

实验方案

Product Specific Protocols
IF protocol for CL594 Thyroglobulin antibody CL594-60272Download protocol
Standard Protocols
Click here to view our Standard Protocols