验证数据展示
产品信息
22126-1-PBS targets Ubiquilin 1 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Applications | WB, IF/ICC, Indirect ELISA Application Description |
| Tested Reactivity | human, mouse, rat |
| Immunogen | Ubiquilin 1 fusion protein Ag17530 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Full Name | ubiquilin 1 |
| Synonyms | UBQLN1, PLIC 1, hPLIC-1, hPLIC1, hPLIC 1 |
| Calculated Molecular Weight | 589 aa, 63 kDa |
| Observed Molecular Weight | 63-71 kDa |
| GenBank Accession Number | BC010066 |
| Gene Symbol | Ubiquilin 1 |
| Gene ID (NCBI) | 29979 |
| RRID | AB_2879000 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9UMX0 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
UBQLN1, also known as DSK2 or Ubiquilin 1, is an ubiquitin-like proteinis contains a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation.Ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. Higher levels of ubiquilin-1 in the brain decreased malformation of the APP molecule which plays a key role in triggering Alzheimers disease.Conversely, lower levels of ubiquilin-1 in the brain were associated with increased malformation of APP (PMID: 21852239). This antibody detects 70kD band of UBQLN1.
