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Uromodulin Polyclonal antibody, PBS Only

Uromodulin Polyclonal Antibody for WB, IHC, IF-P, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, IF-P, Indirect ELISA

Conjugate

Unconjugated

Cat no : 29975-1-PBS

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Synonyms

验证数据展示

  • WB analysis of human urine using 29975-1-AP (same clone as 29975-1-PBS)

    WB analysis of human urine using 29975-1-AP (same clone as 29975-1-PBS)

    human urine sample were subjected to SDS PAGE followed by western blot with 29975-1-AP (Uromodulin antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29975-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 29975-1-AP (same clone as 29975-1-PBS)

    IHC staining of human kidney using 29975-1-AP (same clone as 29975-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 29975-1-AP (Uromodulin antibody) at dilution of 1:10000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29975-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 29975-1-AP (same clone as 29975-1-PBS)

    IHC staining of human kidney using 29975-1-AP (same clone as 29975-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 29975-1-AP (Uromodulin antibody) at dilution of 1:10000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29975-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse kidney using 29975-1-AP (same clone as 29975-1-PBS)

    IF Staining of mouse kidney using 29975-1-AP (same clone as 29975-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed mouse kidney tissue using Uromodulin antibody (29975-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 29975-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse kidney using 29975-1-AP (same clone as 29975-1-PBS)

    IF Staining of mouse kidney using 29975-1-AP (same clone as 29975-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed mouse kidney tissue using Uromodulin antibody (29975-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 29975-1-PBS in a different storage buffer formulation.

产品信息

29975-1-PBS targets Uromodulin in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Applications WB, IHC, IF-P, Indirect ELISA Application Description
Tested Reactivity human, mouse
Immunogen Uromodulin fusion protein Ag32343 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name uromodulin
Synonyms
Calculated Molecular Weight 640 aa, 70 kDa
Observed Molecular Weight80-90 kDa
GenBank Accession NumberBC035975
Gene Symbol Uromodulin
Gene ID (NCBI) 7369
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDP07911
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Uromodulin, also known as THP (Tamm-Horsfall glycoprotein), is the most abundant protein excreted in the urine under physiological conditions. Uromodulin is synthesized by the kidney and localizes in cells lining the ascending limb of Henle and distal convoluted tubule. Uromodulin has been linked to water/electrolyte balance and to kidney innate immunity. Also, studies in knockout mice demonstrated that it has a protective role against urinary tract infections and renal stone formation. Mutations in the gene encoding uromodulin lead to rare autosomal dominant diseases, collectively referred to as uromodulin-associated kidney diseases. (PMID: 21654721)