VWF Monoclonal antibody, PBS Only

VWF Monoclonal Antibody for IHC, IF-P, Indirect ELISA
Cat No. 66682-1-PBS

产品说明书

CloneNo. 3F9F3

宿主/亚型

Mouse / IgG1

种属反应性

human

应用

IHC, IF-P, Indirect ELISA

VWF, VWFpp, VWD, von Willebrand antigen II, F8VWF, 3F9F3

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -


Planning an IHC experiment? We recommend our IHCeasy VWF Ready-To-Use IHC Kit. VWF primary antibody included.

产品信息

66682-1-PBS targets VWF in IHC, IF-P, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 IHC, IF-P, Indirect ELISA Application Description
经测试反应性 human
免疫原 VWF fusion protein Ag25578 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 von Willebrand factor
别名 VWF, VWFpp, VWD, von Willebrand antigen II, F8VWF, 3F9F3
基因名称 VWF
Gene ID (NCBI) 7450
RRIDAB_2882036
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein G purification
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Von Willebrand factor (VWF) is a large multimeric glycoprotein found in blood plasma involved in hemostasis following vascular injury. Due to the multimeric nature of VWF, it can range in size from 500 to 20,000 kDa due to the differences in the number of subunits comprising the protein. Each subunit is approximately 250 kDa (PMID: 9759493). The biosynthesis of VWF in vivo is limited to endothelial cells (PMID: 4209883) and megakaryocytes (PMID: 2413071). VWF synthesized in endothelial cells is either released directly into the plasma via 27186a secretory pathway, or tubulized and stored in organelles unique to this cell type called Weibel-Palade bodies (PMID: 16459301). Whereas VWF synthesized in megakaryocytes is stored in the alpha granules of platelets (PMID: 2046403). The primary function of VWF is as an adhesive plasma glycoprotein, particularly factor VIII; an essential blood-clotting protein (PMID: 6982084). VWF is also important in platelet adhesion to wound sites by binding specifically to type I and type III collagen (PMID: 11098050), with larger VWF multimers being most effective (PMID: 24448155).

Loading...