VWF Monoclonal antibody, PBS Only

VWF Monoclonal Antibody for Indirect ELISA,IHC,IF

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

Indirect ELISA,IHC,IF

Conjugate

Unconjugated

CloneNo.

3F9F3

Cat No : 66682-1-PBS

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Synonyms

F8VWF, von Willebrand antigen II, von Willebrand factor, VWD, VWF



Planning an IHC experiment? We recommend our IHCeasy VWF Ready-To-Use IHC Kit. VWF primary antibody included.

产品信息

66682-1-PBS targets VWF in IF, IHC, Indirect ELISA applications and shows reactivity with Human samples.

Tested Applications Indirect ELISA,IHC,IF Application Description
Tested Reactivity Human
Immunogen VWF fusion protein Ag25578 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name von Willebrand factor
Synonyms F8VWF, von Willebrand antigen II, von Willebrand factor, VWD, VWF
Gene Symbol VWF
Gene ID (NCBI) 7450
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

背景介绍

Von Willebrand factor (VWF) is a large multimeric glycoprotein found in blood plasma involved in hemostasis following vascular injury. Due to the multimeric nature of VWF, it can range in size from 500 to 20,000 kDa due to the differences in the number of subunits comprising the protein. Each subunit is approximately 250 kDa (PMID: 9759493). The biosynthesis of VWF in vivo is limited to endothelial cells (PMID: 4209883) and megakaryocytes (PMID: 2413071). VWF synthesized in endothelial cells is either released directly into the plasma via 27186a secretory pathway, or tubulized and stored in organelles unique to this cell type called Weibel-Palade bodies (PMID: 16459301). Whereas VWF synthesized in megakaryocytes is stored in the alpha granules of platelets (PMID: 2046403). The primary function of VWF is as an adhesive plasma glycoprotein, particularly factor VIII; an essential blood-clotting protein (PMID: 6982084). VWF is also important in platelet adhesion to wound sites by binding specifically to type I and type III collagen (PMID: 11098050), with larger VWF multimers being most effective (PMID: 24448155).