验证数据展示
产品信息
84877-5-PBS targets WAPL in WB, IHC, IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse samples.
Tested Applications | WB, IHC, IF/ICC, FC (Intra), Indirect ELISA Application Description |
Tested Reactivity | human, mouse |
Immunogen | WAPL fusion protein Ag9585 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Full Name | wings apart-like homolog (Drosophila) |
Synonyms | WAPL/FOE, FOE, 242443C1, WAPL cohesin release factor, WAPAL |
Calculated Molecular Weight | 142 kDa |
Observed Molecular Weight | 160-180 kDa |
GenBank Accession Number | BC017393 |
Gene Symbol | WAPL |
Gene ID (NCBI) | 23063 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purfication |
UNIPROT ID | Q7Z5K2 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
The wings apart-like (WAPL, or WAPAL) protein was originally identified as a gene product that potentially regulates heterochromatin organization in Drosophila melanogaster. Human WAPL is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase. Overexpression of WAPL disturbs mitosis and cytokinesis, and contributes to tumor progression by induction of chromosomal instability. WAPAL has a predicted molecular weight of 140 kDa, however, as a result of its extensive phosphorylation it separates on a SDS gel as a band of approximately 160-180 kDa.