验证数据展示
产品信息
67274-1-PBS targets WWP2 in WB, IHC, Indirect ELISA applications and shows reactivity with Human, Rat samples.
Tested Applications | WB, IHC, Indirect ELISA Application Description |
Tested Reactivity | Human, Rat |
Immunogen | WWP2 fusion protein Ag2835 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | WW domain containing E3 ubiquitin protein ligase 2 |
Synonyms | AIP2, WW domain containing protein 2, WWP2, WWp2 like |
Calculated Molecular Weight | 870 aa, 99 kDa |
Observed Molecular Weight | 100-115 kDa |
GenBank Accession Number | BC013645 |
Gene Symbol | WWP2 |
Gene ID (NCBI) | 11060 |
RRID | AB_2882543 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
UNIPROT ID | O00308 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
WWP2 (WW domain-containing protein 2) is also named as AIP2 and belongs to the NEDD4-like protein family. It functions as an E3 ubiquitin ligase for PTEN that plays a vital role in tumour-cell survival and is also involved in regulating transcription, embryonic stem-cell fate, cellular transport and T-cell activation processes (PMID:21532586). WWP2, which specifically interacted with ES cell-specific transcription factor Oct-4 and promoted its ubiquitination both in vitro and in vivo, is a ubiquitously expressed protein and exists in both cytoplasmic and nuclear compartments in ES cells (PMID:15047715).