验证数据展示
产品信息
80845-1-PBS targets c-MYC in WB, IHC, IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with human samples.
Tested Applications | WB, IHC, IF/ICC, FC (Intra), Indirect ELISA Application Description |
Tested Reactivity | human |
Immunogen | c-MYC fusion protein Ag1263 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Full Name | v-myc myelocytomatosis viral oncogene homolog (avian) |
Synonyms | MYC, MRTL, Class E basic helix-loop-helix protein 39, c Myc, bHLHe39 |
Calculated Molecular Weight | 49 kDa |
Observed Molecular Weight | 50-65 kDa |
GenBank Accession Number | BC000141 |
Gene Symbol | MYC |
Gene ID (NCBI) | 4609 |
RRID | AB_2918915 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | P01106 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
MYC contains one basic helix-loop-helix (bHLH) domain. This protein is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. It seems to activate the transcription of growth-related genes. It binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma.