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验证数据展示

  • FC experiment of U-937 using 98048-1-RR (same clone as 98048-1-PBS)

    FC experiment of U-937 using 98048-1-RR (same clone as 98048-1-PBS)

    1x10^6 PMA-treated U-937 cells were surface stained with 0.25 ug Anti-Human uPAR/CD87 Rabbit Recombinant Antibody (98048-1-RR, Clone: 240366G10) (red) or isotype control (blue) and PE-conjugated Goat Anti-Rabbit IgG. Untreated U-937 cells were surface stained with 0.25 ug Anti-Human uPAR/CD87 Rabbit Recombinant Antibody (98048-1-RR, Clone: 240366G10) and PE-conjugated Goat Anti-Rabbit IgG (black). Cells were not fixed. This data was developed using the same antibody clone with 98048-1-PBS in a different storage buffer formulation.

  • IF Staining of HeLa using 98048-1-RR (same clone as 98048-1-PBS)

    IF Staining of HeLa using 98048-1-RR (same clone as 98048-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HeLa cells using uPAR/CD87 antibody (98048-1-RR, Clone: 240366G10 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 98048-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98048-1-RR

    Affinity and Kinetic Characterization of 98048-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98048-1-RR against Human uPAR were performed. The affinity constant is 4.70 nM.

Anti-Human uPAR/CD87 Rabbit Recombinant Antibody, PBS Only

uPAR/CD87 Uni-rAbTM Recombinant Antibody for IF/ICC, FC
Cat No. 98048-1-PBS

产品说明书

CloneNo. 240366G10

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IF/ICC, FC

别名

PLAUR, UPAR, U PAR, MO3, CD87

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

98048-1-PBS targets uPAR/CD87 in IF/ICC, FC applications and shows reactivity with human samples.

经测试应用 IF/ICC, FC Application Description
经测试反应性 human
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 PLAUR
别名 PLAUR, UPAR, U PAR, MO3, CD87
计算分子量37 kDa
GenBank蛋白编号NM_002659.4
基因名称 uPAR
Gene ID (NCBI) 5329
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDQ03405-1
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

uPAR, also known as CD87, is a highly glycosylated, GPI-anchored membrane protein. In addition to the membrane-anchored form, uPAR is released from the plasma membrane by cleavage of the GPI anchor and can be found as a soluble form (suPAR). uPAR contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, uPA cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodeling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559)