Anti-Human uPAR/CD87 Rabbit Recombinant Antibody
uPAR/CD87 Uni-rAbTM Recombinant Antibody for IF/ICC, FC
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
IF/ICC, FC
Conjugate
Unconjugated
CloneNo.
240366G10
验证数据展示
经过测试的应用
| Positive IF/ICC detected in | HeLa cells |
| Positive FC detected in | PMA treated U-937 cells |
推荐稀释比
| Application | Dilution |
|---|---|
| Immunofluorescence (IF)/ICC | IF/ICC : 1:200-1:800 |
| This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
98048-1-RR targets uPAR/CD87 in IF/ICC, FC applications and shows reactivity with human samples.
| Tested Applications | IF/ICC, FC Application Description |
| Tested Reactivity | human |
| Immunogen | Recombinant protein 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Full Name | PLAUR |
| Synonyms | PLAUR, UPAR, U PAR, MO3, CD87 |
| Calculated Molecular Weight | 37 kDa |
| GenBank Accession Number | NM_002659.4 |
| Gene Symbol | uPAR |
| Gene ID (NCBI) | 5329 |
| RRID | AB_3672195 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purfication |
| UNIPROT ID | Q03405-1 |
| Storage Buffer | PBS with 0.09% sodium azide. |
| Storage Conditions | Store at 2-8°C. Stable for one year after shipment. |
背景介绍
uPAR, also known as CD87, is a highly glycosylated, GPI-anchored membrane protein. In addition to the membrane-anchored form, uPAR is released from the plasma membrane by cleavage of the GPI anchor and can be found as a soluble form (suPAR). uPAR contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, uPA cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodeling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559)
实验方案
| Product Specific Protocols | |
|---|---|
| IF protocol for uPAR/CD87 antibody 98048-1-RR | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |