CoraLite® Plus 405 Anti-Human uPAR/CD87 Rabbit Recombinant Antibody

uPAR/CD87 Uni-rAbTM Recombinant Antibody for FC
Cat No. CL405-98048

产品说明书

CloneNo. 240366G10

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

PLAUR, UPAR, U PAR, MO3, CD87

缓冲液配方:  PBS and Azide
PBS and Azide
规格: 

-/ -


经过测试的应用

Positive FC detected inPMA treated U-937 cells
For other applications, we recommend the unconjugated version of this antibody, 98048-1-PBS

推荐稀释比

应用推荐稀释比
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.
Sample-dependent, Check data in validation data gallery.

产品信息

CL405-98048 targets uPAR/CD87 in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 Fusion Protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 PLAUR
别名 PLAUR, UPAR, U PAR, MO3, CD87
计算分子量37 kDa
GenBank蛋白编号NM_002659.4
基因名称 uPAR
Gene ID (NCBI) 5329
RRIDAB_3672422
偶联类型 CoraLite® Plus 405 Fluorescent Dye
最大激发/发射波长399 nm / 422 nm
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ03405-1
储存缓冲液 PBS with 0.09% sodium azide and 0.5% BSA , pH 7.3
储存条件Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

背景介绍

uPAR, also known as CD87, is a highly glycosylated, GPI-anchored membrane protein. In addition to the membrane-anchored form, uPAR is released from the plasma membrane by cleavage of the GPI anchor and can be found as a soluble form (suPAR). uPAR contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, uPA cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodeling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559)

实验方案

Product Specific Protocols
FC protocol for CL Plus 405 uPAR/CD87 antibody CL405-98048Download protocol
Standard Protocols
Click here to view our Standard Protocols
Loading...