CoraLite® Plus 488-conjugated BRE Monoclonal antibody
BRE Monoclonal Antibody for IF-P
Host / Isotype
Mouse / IgG2a
Reactivity
human, rat, mouse
Applications
IF-P
Conjugate
CoraLite® Plus 488 Fluorescent Dye
CloneNo.
2E5A5
验证数据展示
经过测试的应用
| Positive IF-P detected in | mouse brain tissue |
For other applications, we recommend the unconjugated version of this antibody, 66356-1-Ig
推荐稀释比
| Application | Dilution |
|---|---|
| Immunofluorescence (IF)-P | IF-P : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
CL488-66356 targets BRE in IF-P applications and shows reactivity with human, rat, mouse samples.
| Tested Applications | IF-P Application Description |
| Tested Reactivity | human, rat, mouse |
| Immunogen | BRE fusion protein Ag2256 种属同源性预测 |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | brain and reproductive organ-expressed (TNFRSF1A modulator) |
| Synonyms | BRCA1 A complex subunit BRE, BRCC4, BRCC45, BRE |
| Calculated Molecular Weight | 383 aa, 44 kDa |
| Observed Molecular Weight | 42-47 kDa |
| GenBank Accession Number | BC001251 |
| Gene Symbol | BRE |
| Gene ID (NCBI) | 9577 |
| RRID | AB_2919314 |
| Conjugate | CoraLite® Plus 488 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 493 nm / 522 nm |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q9NXR7 |
| Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
BRE, also named as BRCC45, is a death receptor-associated antiapoptotic protein, which is also involved in DNA-damage repair, and K63-specific deubiquitination. BRE and its XIAP-sustaining mechanism could represent novel targets for anti-cancer therapy. BRE may regulate TNF-alpha signaling through its interactions with TNFRSF1A. It plays a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. BRE gene has four isoforms with MW 42-47 kDa.
实验方案
| Product Specific Protocols | |
|---|---|
| IF protocol for CL Plus 488 BRE antibody CL488-66356 | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |