APC Anti-Mouse CD11b (M1/70)

CD11b Monoclonal Antibody for FC
Cat No. APC-65055

产品说明书

CloneNo. M1/70

宿主/亚型

Rat / IgG2b, kappa

种属反应性

mouse and More (1)

应用

FC

M1/70, Ly 40, Itgam, integrin alpha M, CR3A

缓冲液配方:  PBS and Azide
PBS and Azide
规格: 

-/ -


经过测试的应用

Positive FC detected inC57BL/6 mouse bone marrow cells

推荐稀释比

应用推荐稀释比
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

发表文章中的应用

FCSee 8 publications below

产品信息

APC-65055 targets CD11b in FC applications and shows reactivity with mouse samples.

经测试应用 FC Application Description
文献引用应用FC
经测试反应性 mouse
文献引用反应性human, mouse
免疫原 C57BL/10 mouse splenic T cells and concanavalin A-activated C57BL/10 splenocytes 种属同源性预测
宿主/亚型 Rat / IgG2b, kappa
抗体类别 Monoclonal
产品类型 Antibody
全称 integrin alpha M
别名 M1/70, Ly 40, Itgam, integrin alpha M, CR3A
计算分子量127 kDa
GenBank蛋白编号BC156991
基因名称 CD11b
Gene ID (NCBI) 16409
RRIDAB_2882958
偶联类型 APC Fluorescent Dye
最大激发/发射波长650 nm / 660 nm
形式 Liquid
纯化方式Affinity purification
UNIPROT IDE9Q604
储存缓冲液 PBS with 0.09% sodium azide and 0.5% BSA , pH 7.3
储存条件Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

背景介绍

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11b, also known as Integrin alpha M or CR3A, belongs to the integrin alpha chain family. CD11b forms an α/β heterodimer with CD18 (integrin β2). CD11b/CD18 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PMID: 9558116; 20008295). CD11b/CD18 is a receptor for the complement protein fragment iC3b, and is also a receptor for fibrinogen, factor X and ICAM1 (PMID: 2971974; 15485828).

实验方案

Product Specific Protocols
FC protocol for APC CD11b antibody APC-65055Download protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
mouseFC

Adv Sci (Weinh)

Cancer-Associated Fibroblast-Induced Remodeling of Tumor Microenvironment in Recurrent Bladder Cancer

Authors - Ting Liang
FC

J Nanobiotechnology

PD-L1 blockade TAM-dependently potentiates mild photothermal therapy against triple-negative breast cancer

Authors - Chao Wang
FC

Int Immunopharmacol

EGFR-TNFR1 pathway in endothelial cell facilitates acute lung injury by NF-κB/MAPK-mediated inflammation and RIP3-dependent necroptosis

Authors - Huiling Zhang
human,mouseFC

Cell Death Dis

EGFR tyrosine kinase activity and Rab GTPases coordinate EGFR trafficking to regulate macrophage activation in sepsis

Authors - Xuedi Zhang
mouseFC

Front Bioeng Biotechnol

Vascular endothelial growth factor attenuates neointimal hyperplasia of decellularized small-diameter vascular grafts by modulating the local inflammatory response

Authors - Xinlong Xie
mouseFC

Int Immunopharmacol

Neutrophil PPIF exacerbates lung ischemia-reperfusion injury after lung transplantation by promoting calcium overload-induced neutrophil extracellular traps formation

Authors - Wensi Wu
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