CoraLite®594 Anti-Mouse CD126/IL-6R alpha Rabbit Recombinant Antibody

CD126/IL-6R alpha Uni-rAbTM Recombinant Antibody for FC
Cat No. CL594-98024
CloneNo. 230371A7

Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

FC

Il6ra, CD126, 230371A7, IL-6R alpha, Il6r

Formulation:  PBS and Azide
PBS and Azide
Size: 

-/ -


经过测试的应用

Positive FC detected inmouse splenocytes
For other applications, we recommend the unconjugated version of this antibody, 98024-1-PBS

推荐稀释比

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL594-98024 targets CD126/IL-6R alpha in FC applications and shows reactivity with mouse samples.

Tested Applications FC Application Description
Tested Reactivity mouse
Immunogen Fusion Protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name interleukin 6 receptor, alpha
Synonyms Il6ra, CD126, 230371A7, IL-6R alpha, Il6r
Calculated Molecular Weight50KD
GenBank Accession NumberNM_010559.3
Gene Symbol Il6ra
Gene ID (NCBI) 16194
RRIDAB_3673544
Conjugate CoraLite®594 Fluorescent Dye
Excitation/Emission Maxima Wavelengths588 nm / 604 nm
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP22272
Storage Buffer PBS with 0.09% sodium azide.
Storage ConditionsStore at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

背景介绍

Interleukin-6 (IL-6) is a pleiotropic cytokine produced by a variety of cells during infection, trauma, and immunological challenge (PMID: 8274730). IL-6 acts via a receptor complex consisting of two distinct membrane-bound glycoproteins, an 80-kDa IL-6-binding subunit (IL-6R alpha, CD126, gp80) and a 130-kDa signal-transducing element (gp130, CD130). After binding of IL-6 to membrane-bound IL-6R alpha, the complex of IL-6 and IL-6R alpha associates with gp130, thus activating the receptor (PMID: 9716487). Expression of gp130 is found in almost all organs while expression of IL-6R alpha is predominantly confined to hepatocytes and leukocyte subpopulations (monocytes, neutrophils, T cells, and B cells) (PMID: 11149892).

实验方案

Product Specific Protocols
FC protocol for CL594 CD126/IL-6R alpha antibody CL594-98024Download protocol
Standard Protocols
Click here to view our Standard Protocols
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