CoraLite® Plus 488 Anti-Human CD141/Thrombomodulin Rabbit Recombinant Antibody
CD141/Thrombomodulin Uni-rAbTM Recombinant Antibody for FC
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
FC
Conjugate
CoraLite® Plus 488 Fluorescent Dye
CloneNo.
240365E11
验证数据展示
经过测试的应用
| Positive FC detected in | human peripheral blood leukocytes, FC receptor blocked human peripheral blood leukocytes |
For other applications, we recommend the unconjugated version of this antibody, 98037-1-PBS
推荐稀释比
| Application | Dilution |
|---|---|
| This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
The immunogen of CL488-98037 is CD141/Thrombomodulin Fusion Protein expressed in E. coli.
| Tested Applications | FC Application Description |
| Tested Reactivity | human |
| Immunogen | Fusion Protein 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Full Name | thrombomodulin |
| Synonyms | THBD, Thrombomodulin, THRM, Fetomodulin, CD141 |
| Calculated Molecular Weight | 60 kDa |
| GenBank Accession Number | NM_000361.3 |
| Gene Symbol | THBD |
| Gene ID (NCBI) | 7056 |
| Conjugate | CoraLite® Plus 488 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 493 nm / 522 nm |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P07204 |
| Storage Buffer | PBS with 0.09% sodium azide and 0.5% BSA. |
| Storage Conditions | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
背景介绍
Thrombomodulin, also known as CD141, is an endothelial cell surface glycoprotein that forms a 1:1 complex with the coagulation factor thrombin and plays an important role as a natural anticoagulant. Thrombomodulin serves to convert thrombin from a procoagulant protein into the activator for protein C. Once converted to activated protein C (APC), this protein serves as a major anticoagulant in blood (PMID: 2827310). Thrombomodulin is also located in other cells (keratinocytes, osteoblasts, macrophages,...) where it might be involved in cell differentiation or in inflammation (PMID: 9814688). In humans, thrombomodulin is encoded by the THBD gene. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. Thrombomodulin is glycosylated and has an apparent molecular weight of 75 to 110 kDa (PMID: 1650405; 2827310).
实验方案
| Product Specific Protocols | |
|---|---|
| FC protocol for CL Plus 488 CD141/Thrombomodulin antibody CL488-98037 | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |