PE Anti-Mouse CD3ε (145-2C11)
CD3ε Monoclonal Antibody for FC
Host / Isotype
Hamster / IgG
Reactivity
Mouse and More (1)
Applications
FC and More (1)
Conjugate
PE Fluorescent Dye
CloneNo.
145-2C11
验证数据展示
经过测试的应用
| Positive FC detected in | mouse splenocytes |
推荐稀释比
| Application | Dilution |
|---|---|
| This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
发表文章中的应用
| FC | See 2 publications below |
产品信息
PE-65060 targets CD3ε in FC, FC (Intra) applications and shows reactivity with Mouse samples.
| Tested Applications | FC Application Description |
| Cited Applications | FC, FC (Intra) |
| Tested Reactivity | Mouse |
| Cited Reactivity | mouse |
| Immunogen | H-2Kb-specific murine cytotoxic T-lymphocyte (CTL) clone BM10-37 种属同源性预测 |
| Host / Isotype | Hamster / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | CD3 antigen, epsilon polypeptide |
| Synonyms | AI504783, CD3, CD3e, CD3epsilon, CD3ε, T3e |
| GenBank Accession Number | BC098236 |
| Gene Symbol | CD3ε |
| Gene ID (NCBI) | 12501 |
| RRID | AB_2883857 |
| Conjugate | PE Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 496 nm, 565 nm / 578 nm |
| Form | Liquid |
| Purification Method | Affinity purification |
| UNIPROT ID | P22646 |
| Storage Buffer | PBS with 0.1% sodium azide and a stabilizer. |
| Storage Conditions | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
背景介绍
CD3 is a multimeric protein associated with the T-cell receptor (TCR) to form a complex involved in antigen recognition and signal transduction (PMID: 15885124). CD3 is composed of CD3γ, δ, ε, and ζ chains (PMID: 1826255). It is expressed by thymocytes in a developmentally regulated manner, T cells, and some NK cells (PMID: 3289580). The TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. TCR-mediated peptide-MHC recognition is transmitted to the CD3 complex, leading to the intracellular signal transduction (PMID: 11985657).
实验方案
| Product Specific Protocols | |
|---|---|
| FC protocol for PE CD3ε antibody PE-65060 | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
发表文章
| Species | Application | Title |
|---|---|---|
Adv Healthc Mater Pathogen-mimicking Nanoparticles Based on Rigid Nanomaterials as an Efficient Subunit Vaccine Delivery System for Intranasal Iimmunization | ||
Int J Biol Macromol Mucoadhesive chitosan-catechol as an efficient vaccine delivery system for intranasal immunization | ||
J Adv Res Design of a targeted dual drug delivery system for boosting the efficacy of photoimmunotherapy against melanoma proliferation and metastasis |
