CoraLite® Plus 405 Anti-Mouse CD48 (HM48-1)
CD48 Monoclonal Antibody for FC
Host / Isotype
Armenian Hamster / IgG
Reactivity
mouse
Applications
FC
Conjugate
CoraLite® Plus 405 Fluorescent Dye
CloneNo.
HM48-1
验证数据展示
经过测试的应用
Positive FC detected in | mouse splenocytes |
For other applications, we recommend the unconjugated version of this antibody, 65227-1-Ig
推荐稀释比
Application | Dilution |
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This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
产品信息
CL405-65227 targets CD48 in FC applications and shows reactivity with mouse samples.
Tested Applications | FC Application Description |
Tested Reactivity | mouse |
Immunogen | Mouse T lymphoma MBL-2 种属同源性预测 |
Host / Isotype | Armenian Hamster / IgG |
Class | Monoclonal |
Type | Antibody |
Full Name | CD48 antigen |
Synonyms | MEM 102, HM48-1, CD48 antigen, BLAST1, BLAST 1 |
GenBank Accession Number | BC060977 |
Gene Symbol | Cd48 |
Gene ID (NCBI) | 12506 |
Conjugate | CoraLite® Plus 405 Fluorescent Dye |
Excitation/Emission Maxima Wavelengths | 399 nm / 422 nm |
Form | Liquid |
Purification Method | Affinity purification |
UNIPROT ID | P18181 |
Storage Buffer | PBS with 0.09% sodium azide. |
Storage Conditions | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
背景介绍
Signaling lymphocytic activation molecule family 2 (SLAMF2, CD48) is an adhesion and costimulatory molecule expressed constitutively on most hematopoietic cells, particularly in antigen-presenting cells (APC). CD48 is expressed on all the hematopoietic cells, both in humans and mice, except for murine neutrophils and long-term HSC. CD48 exists as both a membrane-bound (mCD48) and a soluble (sCD48) form. CD48 can activate T cells, antigen-presenting cells and granulocytes, by binding to CD2 or bacterial FimH, and through cell intrinsic effects. Interactions between CD48 and its high-affinity ligand CD244 are more complex, with both stimulatory and inhibitory outcomes. CD48 expression is increased in autoimmunity and allergy diseases, and anti-CD48 monoclonal antibodies have been shown to attenuate experimental autoimmune encephalomyelitis.
实验方案
Product Specific Protocols | |
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FC protocol for CL Plus 405 CD48 antibody CL405-65227 | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |