CoraLite® Plus 647 Anti-Mouse CD48 (HM48-1)
CD48 Monoclonal Antibody for FC
Host / Isotype
Armenian Hamster / IgG
Reactivity
mouse
Applications
FC
Conjugate
CoraLite® Plus 647 Fluorescent Dye
CloneNo.
HM48-1
验证数据展示
经过测试的应用
| Positive FC detected in | mouse splenocytes |
For other applications, we recommend the unconjugated version of this antibody, 65227-1-Ig
推荐稀释比
| Application | Dilution |
|---|---|
| This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
CL647-65227 targets CD48 in FC applications and shows reactivity with mouse samples.
| Tested Applications | FC Application Description |
| Tested Reactivity | mouse |
| Immunogen | Mouse T lymphoma MBL-2 种属同源性预测 |
| Host / Isotype | Armenian Hamster / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | CD48 antigen |
| Synonyms | MEM 102, HM48-1, CD48 antigen, BLAST1, BLAST 1 |
| GenBank Accession Number | BC060977 |
| Gene Symbol | Cd48 |
| Gene ID (NCBI) | 12506 |
| Conjugate | CoraLite® Plus 647 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 654 nm / 674 nm |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P18181 |
| Storage Buffer | PBS with 0.1% sodium azide and 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
背景介绍
Signaling lymphocytic activation molecule family 2 (SLAMF2, CD48) is an adhesion and costimulatory molecule expressed constitutively on most hematopoietic cells, particularly in antigen-presenting cells (APC). CD48 is expressed on all the hematopoietic cells, both in humans and mice, except for murine neutrophils and long-term HSC. CD48 exists as both a membrane-bound (mCD48) and a soluble (sCD48) form. CD48 can activate T cells, antigen-presenting cells and granulocytes, by binding to CD2 or bacterial FimH, and through cell intrinsic effects. Interactions between CD48 and its high-affinity ligand CD244 are more complex, with both stimulatory and inhibitory outcomes. CD48 expression is increased in autoimmunity and allergy diseases, and anti-CD48 monoclonal antibodies have been shown to attenuate experimental autoimmune encephalomyelitis.
实验方案
| Product Specific Protocols | |
|---|---|
| FC protocol for CL Plus 647 CD48 antibody CL647-65227 | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
