Anti-Human CD61 (VIPL2)

CD61 Monoclonal Antibody for FC

Host / Isotype

Mouse / Mouse IgG1 kappa

Reactivity

Human, Non-human primates and More (1)

Applications

FC and More (1)

Conjugate

Unconjugated

CloneNo.

VIPL2

Cat no : 65185-1-Ig

Print datasheet

Synonyms

CD61, GP3A, GPIIIa, Integrin beta 3, ITGB3



经过测试的应用

Positive FC detected inHuman peripheral blood platelets
Planning an IHC experiment? We recommend our IHCeasy ITGB3/CD61 Ready-To-Use IHC Kit. ITGB3/CD61 primary antibody included.

推荐稀释比

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

发表文章中的应用

IFSee 1 publications below

产品信息

65185-1-Ig targets CD61 in IF, FC applications and shows reactivity with Human, Non-human primates samples.

Tested Applications FC Application Description
Cited ApplicationsIF
Tested Reactivity Human, Non-human primates
Cited Reactivityhuman
Immunogen N/A 种属同源性预测
Host / Isotype Mouse / Mouse IgG1 kappa
Class Monoclonal
Type Antibody
Full Name integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Synonyms CD61, GP3A, GPIIIa, Integrin beta 3, ITGB3
Calculated Molecular Weight 788 aa, 87 kDa
GenBank Accession NumberBC127666
Gene Symbol Integrin beta 3
Gene ID (NCBI) 3690
RRIDAB_2881484
Conjugate Unconjugated
Form Liquid
Purification MethodPurified by protein-A affinity chromatography
UNIPROT IDP05106
Storage Buffer PBS with 0.1% sodium azide.
Storage ConditionsStore at 2-8°C.

背景介绍

CD61 is a 110-kDa membrane glycoprotein that is also termed integrin β3 chain or GPIIIa. CD61 can associate with integrin αV chain (CD51) or integrin αIIb chain (CD41, GPIIb) to form heterodimeric receptors for cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, plasminogen, prothrombin, thrombospondin, vitronectin and von Willebrand factor (PMID: 7694604; 9251239; 2018971; 20628538). Integrin αVβ3 (CD51-CD61) is present on endothelium, smooth muscle, osteoclasts, platelets, some fibroblasts, some activated leukocytes and tumor cells (PMID: 7694604). GPllb-llla (CD41-CD61) is restricted in distribution to platelets and cells of megakaryoblastic potential and is required for platelet aggregation (PMID: 2018971; 16322781).

实验方案

Product Specific Protocols
FC protocol for CD61 antibody 65185-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
humanIF

Small Methods

Superresolution Fluorescence Microscopy of Platelet Subcellular Structures as a Potential Tumor Liquid Biopsy

Authors - Peng Xu