验证数据展示
产品信息
66978-1-PBS targets CUL1 in WB, IHC, IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with rat, mouse, human samples.
Tested Applications | WB, IHC, IF/ICC, FC (Intra), Indirect ELISA Application Description |
Tested Reactivity | rat, mouse, human |
Immunogen | CUL1 fusion protein Ag28399 种属同源性预测 |
Host / Isotype | Mouse / IgG2b |
Class | Monoclonal |
Type | Antibody |
Full Name | cullin 1 |
Synonyms | Cullin-1, Cullin1, CUL-1, 1B6D10 |
Calculated Molecular Weight | 90 kDa |
Observed Molecular Weight | 85 kDa |
GenBank Accession Number | BC034318 |
Gene Symbol | CUL1 |
Gene ID (NCBI) | 8454 |
RRID | AB_2882298 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | Q13616 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
The cullin family proteins are scaffold proteins for the Ring finger type E3 ligases. Humans express seven cullin proeins: CUL1-3, CUL4A, CUL4B, CUL5, and CUL7. Each cullin protein can form an E3 ligase similar to the prototype Ring-type E3 ligase Skp1-CUL1-F-box complex. The Cullin-RING-finger type E3 ligases are important regulators in early embryonic development, as highlighted by genetic studies demonstrating that knock-out of CUL1, CUL3, or CUL4A in mice results in early embryonic lethality.