CoraLite®555-conjugated DNM2 Monoclonal antibody

DNM2 Monoclonal Antibody for IF/ICC
Cat No. CL555-68209

产品说明书

CloneNo. 1B8H3

宿主/亚型

Mouse / IgG1

种属反应性

Human, mouse, rat, pig, rabbit

应用

IF/ICC

CMTDI1, CMTDIB, DI CMTB, DNM2, DYN2, dynamin 2, DYNII

缓冲液配方:  PBS and Azide
PBS and Azide
规格: 

-/ -


经过测试的应用

Positive IF/ICC detected inHeLa cells
For other applications, we recommend the unconjugated version of this antibody, 68209-1-Ig

推荐稀释比

应用推荐稀释比
Immunofluorescence (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL555-68209 targets DNM2 in IF/ICC applications and shows reactivity with Human, mouse, rat, pig, rabbit samples.

经测试应用 IF/ICC Application Description
经测试反应性 Human, mouse, rat, pig, rabbit
免疫原 DNM2 fusion protein Ag6274 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 dynamin 2
别名 CMTDI1, CMTDIB, DI CMTB, DNM2, DYN2, dynamin 2, DYNII
计算分子量 98 kDa
观测分子量 100 kDa
GenBank蛋白编号BC054501
基因名称 DNM2
Gene ID (NCBI) 1785
RRIDAB_3084636
偶联类型 CoraLite®555 Fluorescent Dye
最大激发/发射波长557 nm / 570 nm
形式 Liquid
纯化方式Protein G purification
UNIPROT IDP50570
储存缓冲液 PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA , pH 7.3
储存条件Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

DNM2, also known as DYN2, DYNII, CMTDI1, CMTDIB, belongs to the dynamin family. DNM2 is a ubiquitously expressed large GTPase involved in clathrin-dependent and -independent endocytosis and intracellular membrane trafficking. DNM2 plays a role in the regulation of neuron morphology, axon growth, and the formation of neuronal growth cones. Dynamins are associated with microtubules. DNM2 plays an important role in endocytosis and is involved in cytokinesis (PMID: 33713620, 12498685). Mutations in DNM2 cause dominant centronuclear myopathy (PMID: 16227997). Defects in DNM2 are the cause of Charcot-Marie-Tooth disease dominant intermediate type B (CMTDIB) (PMID: 15731758). Alternate splicing results in multiple transcript variants.

实验方案

Product Specific Protocols
IF protocol for CL555 DNM2 antibody CL555-68209Download protocol
Standard Protocols
Click here to view our Standard Protocols
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