验证数据展示
产品信息
83241-1-PBS targets Glypican 2 as part of a matched antibody pair:
MP00156-2: 83241-1-PBS capture and 83241-2-PBS detection (validated in Cytometric bead array)
Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.
This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.
经测试应用 | Cytometric bead array, Indirect ELISA Application Description |
经测试反应性 | human |
免疫原 | Glypican 2 fusion protein Ag4041 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Recombinant |
产品类型 | Antibody |
亲和力 | KD<1.00 x 10-12M KOff<1.00 x 10-6M KOn=1.07 x 105M |
全称 | glypican 2 |
别名 | GPC2, Secreted glypican-2, FLJ38962, 230518A4 |
计算分子量 | 579 aa, 63 kDa |
观测分子量 | 62,70-100 kDa |
GenBank蛋白编号 | BC027972 |
基因名称 | GPC2 |
Gene ID (NCBI) | 221914 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | Q8N158 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
GPC2 (glypican 2), which is expected to be located in cell membrane and extracellular space. It is expressed in lymphoid tissue, skin and testis. The calculated molecular weight of the protein is 62 kDa. GPC2 is mainly active in growing nervous tissues and thyroid cancer tissues (PMID: 28616017). It participates in the growth and differentiation of neuronal axons. Increasing evidence has demonstrated the overexpression of GPC2 in neuroblastoma, a kind of childhood cancer. There is a discovery that GPC2 can be employed as a diagnostic, prognostic, and immunological predictor of generalized cancers. The study may broaden the train of thought toward application of GPC2 in immunotherapy (PMID: 35345673).