PE Anti-Mouse IL-17A Rabbit Recombinant Antibody

IL-17A Uni-rAbTM Recombinant Antibody for FC (Intra)
Cat No. PE-98005

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CloneNo. 230038C7

Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

FC (Intra)

Il17a, Interleukin17A, interleukin 17A, Il17, IL 17A

Formulation:  PBS and Azide
PBS and Azide
Size: 

-/ -


经过测试的应用

Positive FC (Intra) detected inPMA, Ionomycin and Brefeldin A treated C57BL/6 Th17-polarized splenocytes

推荐稀释比

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

PE-98005 targets IL-17A in FC (Intra) applications and shows reactivity with mouse samples.

Tested Applications FC (Intra) Application Description
Tested Reactivity mouse
Immunogen Recombinant protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name interleukin 17A
Synonyms Il17a, Interleukin17A, interleukin 17A, Il17, IL 17A
Calculated Molecular Weight17 kDa
GenBank Accession NumberNM-010552
Gene Symbol Il17a
Gene ID (NCBI) 16171
Conjugate PE Fluorescent Dye
Excitation/Emission Maxima Wavelengths496 nm, 565 nm / 578 nm
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ62386
Storage Buffer PBS with 0.09% sodium azide and 0.5% BSA.
Storage ConditionsStore at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

背景介绍

IL-17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.

实验方案

Product Specific Protocols
FC protocol for PE IL-17A antibody PE-98005Download protocol
Standard Protocols
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