CoraLite®594 Anti-Mouse IL-17A Rabbit Recombinant Antibody
IL-17A Uni-rAbTM Recombinant Antibody for FC (Intra)
Host / Isotype
Rabbit / IgG
Reactivity
mouse
Applications
FC (Intra)
Conjugate
CoraLite®594 Fluorescent Dye
CloneNo.
230038C7
验证数据展示
经过测试的应用
Positive FC (Intra) detected in | PMA, Ionomycin and Brefeldin A treated C57BL/6 Th17-polarized splenocytes |
For other applications, we recommend the unconjugated version of this antibody, 98005-1-PBS
推荐稀释比
Application | Dilution |
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This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
产品信息
CL594-98005 targets IL-17A in FC (Intra) applications and shows reactivity with mouse samples.
Tested Applications | FC (Intra) Application Description |
Tested Reactivity | mouse |
Immunogen | Recombinant protein 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Full Name | interleukin 17A |
Synonyms | Il17a, Interleukin17A, interleukin 17A, Il17, IL 17A |
Calculated Molecular Weight | 17 kDa |
GenBank Accession Number | NM-010552 |
Gene Symbol | Il17a |
Gene ID (NCBI) | 16171 |
Conjugate | CoraLite®594 Fluorescent Dye |
Excitation/Emission Maxima Wavelengths | 588 nm / 604 nm |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | Q62386 |
Storage Buffer | PBS with 0.09% sodium azide. |
Storage Conditions | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
背景介绍
IL-17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.
实验方案
Product Specific Protocols | |
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FC protocol for CL594 IL-17A antibody CL594-98005 | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |