CoraLite® Plus 647 Anti-Mouse IL-17A Rabbit Recombinant Antibody

IL-17A Uni-rAbTM Recombinant Antibody for FC (Intra)
Cat No. CL647-98005

产品说明书

CloneNo. 230038C7

宿主/亚型

Rabbit / IgG

种属反应性

mouse

应用

FC (Intra)

Il17a, Interleukin17A, interleukin 17A, Il17, IL 17A

缓冲液配方:  PBS and Azide
PBS and Azide
规格: 

-/ -


经过测试的应用

Positive FC (Intra) detected inPMA and ionomycin treated C57BL/6 Th17-polarized splenocytes
For other applications, we recommend the unconjugated version of this antibody, 98005-1-PBS

推荐稀释比

应用推荐稀释比
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL647-98005 targets IL-17A in FC (Intra) applications and shows reactivity with mouse samples.

经测试应用 FC (Intra) Application Description
经测试反应性 mouse
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 interleukin 17A
别名 Il17a, Interleukin17A, interleukin 17A, Il17, IL 17A
计算分子量17 kDa
GenBank蛋白编号NM-010552
基因名称 Il17a
Gene ID (NCBI) 16171
RRIDAB_3673654
偶联类型 CoraLite® Plus 647 Fluorescent Dye
最大激发/发射波长654 nm / 674 nm
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ62386
储存缓冲液 PBS with 0.09% sodium azide , pH 7.3
储存条件Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

背景介绍

IL-17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.

实验方案

Product Specific Protocols
FC protocol for CL Plus 647 IL-17A antibody CL647-98005Download protocol
Standard Protocols
Click here to view our Standard Protocols
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