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验证数据展示

  • FC experiment of human PBMCs using 98203-1-RR (same clone as 98203-1-PBS)

    FC experiment of human PBMCs using 98203-1-RR (same clone as 98203-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human IL-4RA/CD124 Rabbit Recombinant Antibody (98203-1-RR, Clone:241824D8) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Human CD19. Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98203-1-PBS in a different storage buffer formulation.

  • FC experiment of human PBMCs using 98203-1-RR (same clone as 98203-1-PBS)

    FC experiment of human PBMCs using 98203-1-RR (same clone as 98203-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human IL-4RA/CD124 Rabbit Recombinant Antibody (98203-1-RR, Clone:241824D8) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98203-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98203-1-RR

    Affinity and Kinetic Characterization of 98203-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98203-1-RR against Human IL-4RA/CD124 were performed. The affinity constant is 53.6 pM.

Anti-Human IL-4RA/CD124 Rabbit Recombinant Antibody, PBS Only

IL-4RA/CD124 Uni-rAbTM Recombinant Antibody for FC
Cat No. 98203-1-PBS

产品说明书

CloneNo. 241824D8

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

IL4R, IL 4R subunit alpha, IL 4R alpha, IL 4 receptor subunit alpha, IL 4 binding protein

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

98203-1-PBS targets IL-4RA/CD124 in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 interleukin 4 receptor
别名 IL4R, IL 4R subunit alpha, IL 4R alpha, IL 4 receptor subunit alpha, IL 4 binding protein
计算分子量90 kDa
GenBank蛋白编号NM_000418.4
基因名称 IL-4R
Gene ID (NCBI) 3566
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDP24394-1
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

IL-4 receptor alpha chain (IL-4RA), also known as CD124, is a transmembrane glycoprotein expressed on a wide variety of hematopoietic and non-hematopoietic cells. It is a receptor for both IL-4 and IL-13. IL-4RA can complex with the common gamma chain (IL-2R gamma or CD132) and utilizes JAK1 and JAK2 for signal transduction, while complexes of IL-4RA with IL-13RA1 subunit mediate signals via JAK2 and Tyk2. The IL-4 response is involved in promoting Th2 differentiation. The IL-4/IL-13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation.