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Lamin B2 Recombinant antibody, PBS Only

Lamin B2 Recombinant Antibody for IF, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

Human

Applications

IF, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

230184G4

Cat No : 82801-3-PBS

Print datasheet

Synonyms

LAMB2, lamin B2, LMN2, LMNB2

验证数据展示

  • IF Staining of HepG2 using 82801-3-RR (same clone as 82801-3-PBS)

    IF Staining of HepG2 using 82801-3-RR (same clone as 82801-3-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using Lamin B2 antibody (82801-3-RR, Clone: 230184G4 ) at dilution of 1:800 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-phalloidin (red). This data was developed using the same antibody clone with 82801-3-PBS in a different storage buffer formulation.

  • Affinity experiments of 82801-3-RR

    Affinity experiments of 82801-3-RR

    Biolayer interferometry (BLl) kinetic assays of 82801-3-RR against Human Lamin B2 were performed. The affinity constant is 3.64 nM.

产品信息

82801-3-PBS targets Lamin B2 in IF, Indirect ELISA applications and shows reactivity with Human samples.

Tested Applications IF, Indirect ELISA Application Description
Tested Reactivity Human
Immunogen Lamin B2 fusion protein Ag1335 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name lamin B2
Synonyms LAMB2, lamin B2, LMN2, LMNB2
Calculated Molecular Weight 68 kDa
GenBank Accession NumberBC006551
Gene Symbol LMNB2
Gene ID (NCBI) 84823
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ03252
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

背景介绍

Lamins are nuclear membrane structural components that are important in structural integrity of the nucleus and may also interact with chromatin (PMID: 33033404). Research studies show that lamin B2 knockout mice exhibit neuronal developmental defects and that both proteins are essential for typical brain development (PMID: 20145110). Mutations in Lamin B2 can result in a susceptibility to developing acquired partial lipodystrophy, a rare disorder characterized by the progressive loss of subcutaneous fat in a bilaterally symmetrical fashion (PMID: 16826530).