Thyroglobulin Polyclonal antibody

Thyroglobulin Polyclonal Antibody for IHC,ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IHC,ELISA and More (3)

Conjugate

Unconjugated

Cat No : 21714-1-AP

Print datasheet

Synonyms

AITD3, TG, TGN, thyroglobulin



经过测试的应用

Positive IHC detected inhuman thyroid tissue, human thyroid cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

推荐稀释比

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

The immunogen of 21714-1-AP is Thyroglobulin Fusion Protein expressed in E. coli.

Tested Applications IHC,ELISA
Cited Applications CoIP, IF, WB
Tested Reactivity human
Cited Reactivityhuman
Immunogen Thyroglobulin fusion protein Ag16343 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name thyroglobulin
Synonyms AITD3, TG, TGN, thyroglobulin
Calculated Molecular Weight 2768 aa, 305 kDa
GenBank Accession NumberBC140933
Gene Symbol TG
Gene ID (NCBI) 7038
RRIDAB_2878909
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDP01266
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.

实验方案

Product Specific Protocols
IHC protocol for Thyroglobulin antibody 21714-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
humanWB

Mol Cell Proteomics

Thyroglobulin Interactome Profiling Defines Altered Proteostasis Topology Associated With Thyroid Dyshormonogenesis

Authors - Madison T. Wright
humanWB

Oncotarget

HER inhibitor promotes BRAF/MEK inhibitor-induced redifferentiation in papillary thyroid cancer harboring BRAFV600E.

Authors - Lingxiao Cheng
CoIP

Mol Cell Proteomics

Thyroglobulin Interactome Profiling Defines Altered Proteostasis Topology Associated With Thyroid Dyshormonogenesis.

Authors - Madison T Wright
humanIF

J Lipid Res

Differential contributions of choline phosphotransferases CPT1 and CEPT1 to the biosynthesis of choline phospholipid.

Authors - Yasuhiro Horibata
humanWB

Cancer Lett

Epigenetic inhibition of CTCF by HN1 promotes dedifferentiation and stemness of anaplastic thyroid cancer

Authors - Zongfu Pan