验证数据展示
经过测试的应用
Positive FC detected in | mouse splenocytes |
推荐稀释比
应用 | 推荐稀释比 |
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This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
产品信息
CL594-65130 targets CD11c in FC applications and shows reactivity with Mouse samples.
经测试应用 | FC Application Description |
经测试反应性 | Mouse |
免疫原 | Mouse spleen dendritic cells 种属同源性预测 |
宿主/亚型 | Armenian Hamster / IgG |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | integrin alpha X |
别名 | AI449405, Cd11c, Cr4, integrin alpha X, Itgax, N418 |
GenBank蛋白编号 | BC167225 |
基因名称 | CD11c |
Gene ID (NCBI) | 16411 |
RRID | AB_3084669 |
偶联类型 | CoraLite®594 Fluorescent Dye |
最大激发/发射波长 | 588 nm / 604 nm |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | Q9QXH4 |
储存缓冲液 | PBS with 0.09% sodium azide and 0.5% BSA , pH 7.3 |
储存条件 | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
背景介绍
Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11c, also known as integrin αX, is a type I transmembrane glycoprotein present on a variety of cells, including monocytes/macrophages, granulocytes, a subset of B cells, NK cells and dendritic cells (PMID: 2897326; 1680915; 1694698; 17389580). As a result of its high level of expression on most dendritic cells, CD11c is typically considered to be a marker of conventional dendritic cells (PMID: 27119555). CD11c forms an α/β heterodimer with CD18 (integrin β2). CD11c/CD18 acts a receptor for fibrinogen and is important in monocyte adhesion and chemotaxis (PMID: 1671533).
实验方案
Product Specific Protocols | |
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FC protocol for CL594 CD11c antibody CL594-65130 | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |